Smalley C A, Addy D P, Anderson C M
Lancet. 1978 Aug 19;2(8086):415-7. doi: 10.1016/s0140-6736(78)91878-0.
A diagnosis of cystic fibrosis was incorrectly made after false-positive sweat tests in 14 children. 13 of these children had been tested at hospitals where it seems likely that sweat tests were not done very often. All the children had normal sweat-electrolyte values when the test was repeated at a regional paediatric centre where approximately 250 sweat tests are done each year. In 5 cases, detailed testing of pancreatic function was normal. None of the children had typical chest disease and only 2 had gastrointestinal symptoms. In the absence of the typical clinical features of the disease a diagnosis of cystic fibrosis should be made with extreme caution and only after meticulous testing of both sweat electrolytes and pancreatic function.
14名儿童因汗液测试呈假阳性而被错误诊断为囊性纤维化。其中13名儿童是在那些似乎不常进行汗液测试的医院接受检测的。当在一家每年大约进行250次汗液测试的地区儿科中心重复进行测试时，所有儿童的汗液电解质值均正常。在5例病例中，胰腺功能的详细检测结果正常。这些儿童均无典型的胸部疾病，只有2名儿童有胃肠道症状。在缺乏该疾病典型临床特征的情况下，应极其谨慎地做出囊性纤维化的诊断，并且仅在对汗液电解质和胰腺功能进行细致检测之后方可诊断。
