肺炎患儿肺炎衣原体分离株对克拉霉素和红霉素的敏感性
Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia.
作者信息
Roblin P M, Montalban G, Hammerschlag M R
机构信息
Department of Pediatrics, SUNY Health Science Center at Brooklyn 11203-2098.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1588-9. doi: 10.1128/AAC.38.7.1588.
Abstract
We tested in vitro 49 isolates of Chlamydia pneumoniae obtained from 35 children with community-acquired pneumonia against clarithromycin and erythromycin. The children were part of a treatment study comparing the two drugs. Clarithromycin was 2- to 10-fold more active than erythromycin, with a MIC for 90% of strains tested and minimal chlamydiacidal concentration for 90% of strains tested of 0.031 microgram/ml compared with 0.125 microgram/ml for erythromycin. Eight of these children, two of whom were treated with erythromycin and six of whom received clarithromycin, remained culture positive after treatment. We were able to test 21 isolates from these children. All were susceptible to both drugs, and the MICs did not change after therapy.
摘要
我们对从35名社区获得性肺炎儿童中分离出的49株肺炎衣原体进行了体外克拉霉素和红霉素药敏试验。这些儿童是比较这两种药物的一项治疗研究的一部分。克拉霉素的活性比红霉素高2至10倍，90%受试菌株的最低抑菌浓度（MIC）以及90%受试菌株的最低杀衣原体浓度为0.031微克/毫升，而红霉素为0.125微克/毫升。这些儿童中有8名治疗后培养仍呈阳性，其中2名接受红霉素治疗，6名接受克拉霉素治疗。我们对这些儿童的21株分离株进行了检测。所有分离株对两种药物均敏感，且治疗后MIC未发生变化。
相似文献
1
Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia.肺炎患儿肺炎衣原体分离株对克拉霉素和红霉素的敏感性
Antimicrob Agents Chemother. 1994 Jul;38(7):1588-9. doi: 10.1128/AAC.38.7.1588.
2
Microbiologic efficacy of moxifloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae.莫西沙星治疗肺炎衣原体所致社区获得性肺炎的微生物学疗效。
Int J Antimicrob Agents. 2000 Jul;15(2):149-52. doi: 10.1016/s0924-8579(00)00157-6.
3
Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae.ABT-773（塞曲霉素）治疗肺炎衣原体所致社区获得性肺炎的微生物学疗效。
J Antimicrob Chemother. 2003 Apr;51(4):1025-8. doi: 10.1093/jac/dkg154. Epub 2003 Feb 25.
4
Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia.阿奇霉素对成人和儿童社区获得性肺炎患者肺炎衣原体分离株的微生物学疗效及肺炎衣原体分离株对阿奇霉素的敏感性
Antimicrob Agents Chemother. 1998 Jan;42(1):194-6. doi: 10.1128/AAC.42.1.194.
5
In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae.阿奇霉素、克拉霉素、左旋氧氟沙星及其他抗生素对肺炎衣原体的体外活性
Antimicrob Agents Chemother. 1992 Jul;36(7):1573-4. doi: 10.1128/AAC.36.7.1573.
6
In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae.阿奇霉素、克拉霉素、红霉素和四环素对13株肺炎衣原体的体外活性
Antimicrob Agents Chemother. 1996 Jan;40(1):212-4. doi: 10.1128/AAC.40.1.212.
7
In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae.新型抗菌酮内酯类药物塞曲霉素对肺炎衣原体的体外活性
J Antimicrob Chemother. 2003 Sep;52(3):497-9. doi: 10.1093/jac/dkg371. Epub 2003 Aug 13.
8
In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.新型氟喹诺酮类抗生素 CEM-101 对沙眼衣原体和肺炎衣原体（衣原体属）的体外活性。
Antimicrob Agents Chemother. 2010 Mar;54(3):1358-9. doi: 10.1128/AAC.01343-09. Epub 2009 Dec 28.
9
In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae.新型酮内酯类抗生素ABT 773对肺炎衣原体的体外活性
Antimicrob Agents Chemother. 2000 Apr;44(4):1112-3. doi: 10.1128/AAC.44.4.1112-1113.2000.
10
Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate.小儿社区获得性肺炎中的肺炎支原体和肺炎衣原体：克拉霉素与琥乙红霉素的疗效及安全性比较
Pediatr Infect Dis J. 1995 Jun;14(6):471-7. doi: 10.1097/00006454-199506000-00002.
引用本文的文献
1
From coughs to complications: the story of .从咳嗽到并发症：……的故事
J Med Microbiol. 2025 Apr;74(4). doi: 10.1099/jmm.0.002006.
2
In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.新型氟喹诺酮类抗生素 CEM-101 对沙眼衣原体和肺炎衣原体（衣原体属）的体外活性。
Antimicrob Agents Chemother. 2010 Mar;54(3):1358-9. doi: 10.1128/AAC.01343-09. Epub 2009 Dec 28.
3
Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp.衣原体属中赋予抗生素抗性的自发突变频率
Antimicrob Agents Chemother. 2005 Jul;49(7):2865-73. doi: 10.1128/AAC.49.7.2865-2873.2005.
4
Telithromycin treatment of chronic Chlamydia pneumoniae infection in C57BL/6J mice.替利霉素治疗C57BL/6J小鼠慢性肺炎衣原体感染
Antimicrob Agents Chemother. 2004 Oct;48(10):3655-61. doi: 10.1128/AAC.48.10.3655-3661.2004.
5
Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae.用于检测肺炎衣原体大环内酯耐药性的基于基因和培养的方法。
Antimicrob Agents Chemother. 2004 Sep;48(9):3586-90. doi: 10.1128/AAC.48.9.3586-3590.2004.
6
Chlamydia pneumoniae resists antibiotics in lymphocytes.肺炎衣原体对淋巴细胞中的抗生素具有抗性。
Antimicrob Agents Chemother. 2003 Jun;47(6):1972-5. doi: 10.1128/AAC.47.6.1972-1975.2003.
7
Chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies.肺炎衣原体与动脉粥样硬化：诊断方法的批判性评估及其与治疗研究的相关性
Clin Microbiol Rev. 2002 Jan;15(1):1-20. doi: 10.1128/CMR.15.1.1-20.2002.
8
Asthma in children: are chlamydia or mycoplasma involved?儿童哮喘：是否与衣原体或支原体有关？
Paediatr Drugs. 2001;3(3):159-68. doi: 10.2165/00128072-200103030-00001.
9
In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae.新型酮内酯类抗生素ABT 773对肺炎衣原体的体外活性
Antimicrob Agents Chemother. 2000 Apr;44(4):1112-3. doi: 10.1128/AAC.44.4.1112-1113.2000.
10
Activity of quinolones against Chlamydia pneumoniae.喹诺酮类药物对肺炎衣原体的活性。
Drugs. 1999;58 Suppl 2:78-81. doi: 10.2165/00003495-199958002-00015.
本文引用的文献
1
Relative resistance to erythromycin in Chlamydia trachomatis.沙眼衣原体对红霉素的相对耐药性。
Antimicrob Agents Chemother. 1980 Nov;18(5):696-8. doi: 10.1128/AAC.18.5.696.
2
A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections.一种新的鹦鹉热衣原体菌株，TWAR，在急性呼吸道感染中分离得到。
N Engl J Med. 1986 Jul 17;315(3):161-8. doi: 10.1056/NEJM198607173150305.
3
Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics.对多种抗生素耐药的沙眼衣原体分离株的部分特性分析
J Infect Dis. 1990 Dec;162(6):1309-15. doi: 10.1093/infdis/162.6.1309.
4
A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR.一种新的呼吸道病原体：肺炎衣原体TWAR株。
J Infect Dis. 1990 Apr;161(4):618-25. doi: 10.1093/infdis/161.4.618.
5
The diffusion of clarithromycin and roxithromycin into nasal mucosa, tonsil and lung in humans.克拉霉素和罗红霉素在人体鼻黏膜、扁桃体及肺部的扩散情况。
J Antimicrob Chemother. 1991 Feb;27 Suppl A:61-5. doi: 10.1093/jac/27.suppl_a.61.
6
Persistent infection with Chlamydia pneumoniae following acute respiratory illness.急性呼吸道疾病后肺炎衣原体的持续感染。
Clin Infect Dis. 1992 Jan;14(1):178-82. doi: 10.1093/clinids/14.1.178.
7
In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae.阿奇霉素、克拉霉素、左旋氧氟沙星及其他抗生素对肺炎衣原体的体外活性
Antimicrob Agents Chemother. 1992 Jul;36(7):1573-4. doi: 10.1128/AAC.36.7.1573.
Zotero 插件