Marshall R J, Flanigan T P
Case Western Reserve School of Medicine, Cleveland, Ohio.
J Infect Dis. 1992 Apr;165(4):772-4. doi: 10.1093/infdis/165.4.772.
Cryptosporidium parvum is a protozoan parasite that causes severe enteritis in patients with AIDS for which there is no effective therapy. Paromomycin is a nonabsorbable aminoglycoside that is effective in the treatment of other intestinal protozoa. The ability of paromomycin to inhibit C. parvum infection of a differentiated human enterocyte cell line was evaluated in vitro. Paromomycin concentrations ranging from 50 to 5000 micrograms/ml inhibited infection at 24 h in a dose-dependent fashion. Concentrations greater than 1000 micrograms/ml, which are theoretically achievable in the bowel lumen, inhibited infection by greater than 85% (P less than .001). Prospective clinical trials of paromomycin for the treatment of cryptosporidiosis in patients with AIDS are warranted.
微小隐孢子虫是一种原生动物寄生虫，可导致艾滋病患者发生严重肠炎，目前尚无有效治疗方法。巴龙霉素是一种不可吸收的氨基糖苷类药物，对其他肠道原生动物有效。体外评估了巴龙霉素抑制分化的人肠上皮细胞系感染微小隐孢子虫的能力。浓度范围为50至5000微克/毫升的巴龙霉素在24小时时以剂量依赖方式抑制感染。大于1000微克/毫升的浓度在理论上可在肠腔内达到，抑制感染率大于85%（P小于0.001）。有必要对巴龙霉素治疗艾滋病患者隐孢子虫病进行前瞻性临床试验。
