早产儿的低碳酸血症与脑室周围白质软化症
Hypocarbia and cystic periventricular leukomalacia in premature infants.
作者信息
Fujimoto S, Togari H, Yamaguchi N, Mizutani F, Suzuki S, Sobajima H
机构信息
Department of Paediatrics, Nagoya City University Medical School, Japan.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F107-10. doi: 10.1136/fn.71.2.f107.
One hundred sixty seven survivors among very low birthweight infants with a gestational age of less than 35 weeks have been studied prospectively. The purpose of this study was to clarify the relationship of severe prenatal and perinatal complications and hypocarbic alkalosis, defined as a carbon dioxide tension (PaCO2) of less than or equal to 2.67 kPa and a pH of 7.50 or greater during the first 24 hours of life, to cystic periventricular leukomalacia (PVL) depicted by serial cranial ultrasonographic examinations. Complications occurred in 16 infants, five of whom presented with PVL, while eight of 151 infants without complications had PVL. Twenty six of the infants had hypocarbic alkalosis, six with evidence of PVL, and seven of the 136 infants without hypocarbic alkalosis had PVL. These results suggest a significant relationship of complications and hypocarbic alkalosis to PVL. Mechanical ventilation should be managed carefully in premature infants to avoid PaCO2 of lower than 2.67 kPa.
对167名孕周小于35周的极低出生体重儿幸存者进行了前瞻性研究。本研究的目的是明确严重的产前和围产期并发症以及低碳酸血症性碱中毒（定义为出生后24小时内二氧化碳分压（PaCO2）小于或等于2.67kPa且pH值为7.50或更高）与通过系列头颅超声检查所显示的脑室周围白质软化症（PVL）之间的关系。16名婴儿出现并发症，其中5名患有PVL，而151名无并发症的婴儿中有8名患有PVL。26名婴儿出现低碳酸血症性碱中毒，6名有PVL迹象，136名无低碳酸血症性碱中毒的婴儿中有7名患有PVL。这些结果表明并发症和低碳酸血症性碱中毒与PVL之间存在显著关系。对早产儿进行机械通气时应谨慎管理，以避免PaCO2低于2.67kPa。
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