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类风湿关节炎患者滑液中未检测到结核分枝杆菌DNA。

Absence of Mycobacterium tuberculosis DNA in synovial fluid from patients with rheumatoid arthritis.

作者信息

Jalal H, Millar M, Linton C, Dieppe P

机构信息

Department of Pathology and Microbiology, University of Bristol, United Kingdom.

出版信息

Ann Rheum Dis. 1994 Oct;53(10):695-8. doi: 10.1136/ard.53.10.695.

DOI:10.1136/ard.53.10.695
PMID:7979585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1005439/
Abstract

OBJECTIVES

To determine whether Mycobacterium tuberculosis DNA can be detected in synovial fluid of patients with rheumatoid arthritis (RA).

METHODS

The polymerase chain reaction was applied to cellular components of synovial fluid.

RESULTS

No evidence of M tuberculosis DNA was found in synovial fluid from 31 patients with RA and 13 control patients.

CONCLUSION

The findings do not support a role for persistent M tuberculosis infection in the pathogenesis of RA.

摘要

目的

确定类风湿关节炎（RA）患者的滑液中是否能检测到结核分枝杆菌DNA。

方法

将聚合酶链反应应用于滑液的细胞成分。

结果

在31例RA患者和13例对照患者的滑液中未发现结核分枝杆菌DNA的证据。

结论

这些发现不支持持续性结核分枝杆菌感染在RA发病机制中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/f66cabac020a/annrheumd00498-0076-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/4734184633fb/annrheumd00498-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/b6fcbe644b0b/annrheumd00498-0076-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/f66cabac020a/annrheumd00498-0076-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/4734184633fb/annrheumd00498-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/b6fcbe644b0b/annrheumd00498-0076-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3038/1005439/f66cabac020a/annrheumd00498-0076-c.jpg

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Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis.采用聚合酶链反应检测莱姆关节炎患者滑液中的伯氏疏螺旋体DNA。
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Correcting an immune-response deficiency by creating E alpha gene transgenic mice.
通过创建Eα基因转基因小鼠纠正免疫反应缺陷。
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T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis.T淋巴细胞克隆阐明了实验性关节炎的发病机制并影响其治疗。
Arthritis Rheum. 1985 Aug;28(8):841-5. doi: 10.1002/art.1780280802.
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Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.类风湿关节炎患者血清中针对分枝杆菌抗原的IgG和IgA抗体升高。
Ann Rheum Dis. 1989 Feb;48(2):118-23. doi: 10.1136/ard.48.2.118.
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T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage.类风湿性关节炎患者的T淋巴细胞对与软骨发生交叉反应的部分分枝杆菌表现出增强的反应性。
Lancet. 1986 Aug 9;2(8502):305-9. doi: 10.1016/s0140-6736(86)90003-6.
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Yersinia antigens in synovial-fluid cells from patients with reactive arthritis.反应性关节炎患者滑液细胞中的耶尔森菌抗原
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Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis.早期慢性关节炎中滑液T细胞对分枝杆菌65kD热休克蛋白的反应性
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