Fischer H P, Sharrock C E, Colston M J, Panayi G S
Rheumatology Unit UMDS, Guy's Hospital, London, GB.
Eur J Immunol. 1991 Dec;21(12):2937-41. doi: 10.1002/eji.1830211207.
Recent evidence has pointed to the mycobacterial 65-kDa heat-shock protein (hsp 65) as an antigen that may be important in the pathogenesis of rheumatoid arthritis (RA). Using limiting dilution analysis the frequency of purified protein derivative of tuberculin (PPD) and hsp 65-responsive T cells was measured in paired peripheral blood and synovial fluid samples of patients with RA. There was no increase in the anti-PPD or anti-hsp 65 frequency in synovial fluid compared with peripheral blood. In addition, no difference was found between peripheral blood of RA patients and healthy controls. These results do not support the idea of an important pathogenic role of T cells responding to hsp 65, or a cross-reacting antigen, in RA.
最近的证据表明，分枝杆菌65-kDa热休克蛋白（hsp 65）是一种抗原，可能在类风湿性关节炎（RA）的发病机制中起重要作用。采用有限稀释分析法，在RA患者配对的外周血和滑液样本中检测结核菌素纯蛋白衍生物（PPD）和hsp 65反应性T细胞的频率。与外周血相比，滑液中抗PPD或抗hsp 65的频率没有增加。此外，RA患者的外周血与健康对照之间没有差异。这些结果不支持T细胞对hsp 65或交叉反应抗原作出反应在RA中起重要致病作用的观点。
