Dmitrieva N V
Antibiot Khimioter. 1994 Feb-Mar;39(2-3):52-6.
Clindamycin used alone or in combination with other antimicrobial drugs such as aminoglycosides, dioxidin and fluoroquinolones in the prophylaxis and treatment of infectious complications in oncological patients was shown to be highly efficient. When clindamycin was used prophylactically in combination with netilmicin, the postoperative infectious complications developed in 3 out of 27 patients with tumors of the head and neck, in 1 out of 24 patients with tumors of the rectum and colon and in 3 out of 16 patients with tumors of the female genitalia. The clinical effect was observed in 36 (87.8 per cent) out of 41 patients with postoperative wound infections and in 38 (82.5 per cent) out of 40 patients with pneumonia. Therefore, the use of clindamycin alone or in combination with other antimicrobial drugs is essential in the treatment of infectious complications in oncological patients.
在肿瘤患者感染性并发症的预防和治疗中,单独使用克林霉素或与其他抗菌药物(如氨基糖苷类、二氧化氮和氟喹诺酮类)联合使用显示出高效性。当克林霉素与奈替米星联合预防性使用时,27例头颈部肿瘤患者中有3例出现术后感染性并发症,24例直肠和结肠癌患者中有1例出现,16例女性生殖器肿瘤患者中有3例出现。41例术后伤口感染患者中有36例(87.8%)观察到临床效果,40例肺炎患者中有38例(82.5%)观察到临床效果。因此,单独使用克林霉素或与其他抗菌药物联合使用对于治疗肿瘤患者的感染性并发症至关重要。