在氨基三唑存在的情况下，抗坏血酸和葡萄糖对红细胞过氧化氢酶的失活作用（过氧化氢生成）：过渡金属的作用及其与糖尿病的关联
Erythrocyte catalase inactivation (H2O2 production) by ascorbic acid and glucose in the presence of aminotriazole: role of transition metals and relevance to diabetes.
作者信息
Ou P, Wolff S P
机构信息
Department of Medicine, University College, London, U.K.
出版信息
Biochem J. 1994 Nov 1;303 ( Pt 3)(Pt 3):935-9. doi: 10.1042/bj3030935.
Abstract
Erythrocytes exposed to ascorbic acid in the presence of aminotriazole undergo a dose- and time-dependent inactivation of endogenous catalase which is proportional to environmental hydrogen peroxide (H2O2) concentrations. The production of H2O2 seems to be dependent upon the availability of transition metal chelatable by o-phenanthroline (OPT), although the kinetics of catalase inactivation and H2O2 production by externally added copper ions in the presence of OPT is complex. Furthermore, although glucose is also able to undergo a transition-metal-catalysed oxidation yielding H2O2, the production of H2O2 by glucose seems to be a minor process by comparison with ascorbic acid oxidation. Indeed, on the basis of these data, transition-metal-catalysed ascorbic acid oxidation is likely to be a more important source of oxidative stress in the diabetic state than hyperglycaemia.
摘要
在氨基三唑存在的情况下，暴露于抗坏血酸的红细胞会发生内源性过氧化氢酶的剂量和时间依赖性失活，这与环境过氧化氢（H2O2）浓度成正比。H2O2的产生似乎取决于可被邻菲罗啉（OPT）螯合的过渡金属的可用性，尽管在OPT存在下，外部添加铜离子导致过氧化氢酶失活和H2O2产生的动力学很复杂。此外，虽然葡萄糖也能够经历过渡金属催化的氧化反应生成H2O2，但与抗坏血酸氧化相比，葡萄糖产生H2O2似乎是一个次要过程。事实上，基于这些数据，过渡金属催化的抗坏血酸氧化可能是糖尿病状态下比高血糖更重要的氧化应激来源。
相似文献
1
Erythrocyte catalase inactivation (H2O2 production) by ascorbic acid and glucose in the presence of aminotriazole: role of transition metals and relevance to diabetes.在氨基三唑存在的情况下，抗坏血酸和葡萄糖对红细胞过氧化氢酶的失活作用（过氧化氢生成）：过渡金属的作用及其与糖尿病的关联
Biochem J. 1994 Nov 1;303 ( Pt 3)(Pt 3):935-9. doi: 10.1042/bj3030935.
2
Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro.氨基胍：一种被提议用于糖尿病预防的药物在体外可抑制过氧化氢酶并产生过氧化氢。
Biochem Pharmacol. 1993 Oct 5;46(7):1139-44. doi: 10.1016/0006-2952(93)90461-5.
3
Erythrocyte defenses against hydrogen peroxide: the role of ascorbic acid.红细胞对过氧化氢的防御：抗坏血酸的作用。
Biochim Biophys Acta. 1998 May 8;1380(3):389-95. doi: 10.1016/s0304-4165(98)00005-1.
4
A discontinuous method for catalase determination at 'near physiological' concentrations of H2O2 and its application to the study of H2O2 fluxes within cells.一种用于在“接近生理”浓度的过氧化氢条件下测定过氧化氢酶的间断方法及其在细胞内过氧化氢通量研究中的应用。
J Biochem Biophys Methods. 1996 Jan 11;31(1-2):59-67. doi: 10.1016/0165-022x(95)00039-t.
5
Regulation of hydrogen peroxide generation in cultured endothelial cells.培养的内皮细胞中过氧化氢生成的调节
Am J Respir Cell Mol Biol. 1992 Feb;6(2):175-82. doi: 10.1165/ajrcmb/6.2.175.
6
Hydrogen peroxide production by red blood cells.红细胞产生过氧化氢。
Free Radic Biol Med. 1994 Jan;16(1):123-9. doi: 10.1016/0891-5849(94)90249-6.
7
[Features of the inhibition of catalase activity by 3-amino-1,2,4-triazole in erythrocytes and liver of rats with streptozotocin diabetes].
Ukr Biokhim Zh (1999). 1999 Jan-Feb;71(1):77-82.
8
Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen peroxide.过氧化氢酶和谷胱甘肽氧化还原循环在前房过氧化氢调节中的作用。
Ophthalmic Res. 1991;23(5):284-94. doi: 10.1159/000267124.
9
The interrelationship of superoxide dismutase and peroxidatic enzymes in the red cell.红细胞中超氧化物歧化酶与过氧化物酶的相互关系。
Biochim Biophys Acta. 1979 Feb 9;566(2):253-8. doi: 10.1016/0005-2744(79)90028-7.
10
Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia.高胰岛素血症大鼠氧化应激潜力增强：高胰岛素血症导致肝脏过氧化物酶体过氧化氢生成与分解失衡。
Horm Metab Res. 1999 Apr;31(4):278-82. doi: 10.1055/s-2007-978733.
引用本文的文献
1
Role of Pro-Inflammatory Cytokines and Biochemical Markers in the Pathogenesis of Type 1 Diabetes: Correlation with Age and Glycemic Condition in Diabetic Human Subjects.促炎细胞因子和生化标志物在1型糖尿病发病机制中的作用：与糖尿病患者年龄和血糖状况的相关性
PLoS One. 2016 Aug 30;11(8):e0161548. doi: 10.1371/journal.pone.0161548. eCollection 2016.
2
Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine.高血糖不影响铁介导的培养内皮细胞和肾小管上皮细胞毒性：L-肌肽的影响。
J Diabetes Res. 2016;2016:8710432. doi: 10.1155/2016/8710432. Epub 2015 Dec 14.
3
Diabetes, oxidative stress and physical exercise.糖尿病、氧化应激与体育锻炼。
J Sports Sci Med. 2002 Mar 4;1(1):1-14. eCollection 2002 Mar.
4
Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H₂O₂ scavenger alpha lipoic acid.α-硫辛酸作为 H₂O₂ 清除剂可阻断乙醇诱导的小鼠条件性位置偏爱获得和再巩固。
Psychopharmacology (Berl). 2013 Apr;226(4):673-85. doi: 10.1007/s00213-012-2831-9. Epub 2012 Aug 11.
5
α-Lipoic acid, a scavenging agent for H₂O₂, reduces ethanol-stimulated locomotion in mice.α-硫辛酸是 H₂O₂ 的清除剂，可减少乙醇刺激的小鼠运动。
Psychopharmacology (Berl). 2012 Jan;219(1):171-80. doi: 10.1007/s00213-011-2407-0. Epub 2011 Jul 19.
6
Cell density plays a critical role in ex vivo expansion of T cells for adoptive immunotherapy.细胞密度在用于过继性免疫治疗的T细胞体外扩增中起着关键作用。
J Biomed Biotechnol. 2010;2010:386545. doi: 10.1155/2010/386545. Epub 2010 Jun 30.
本文引用的文献
1
Irreversible reaction of 3-amino-1:2:4-triazole and related inhibitors with the protein of catalase.3-氨基-1:2:4-三唑及相关抑制剂与过氧化氢酶蛋白的不可逆反应。
Biochem J. 1960 Feb;74(2):339-48. doi: 10.1042/bj0740339.
2
A study of the inhibition of catalase by 3-amino-1:2:4:-triazole.3-氨基-1,2,4-三唑对过氧化氢酶抑制作用的研究。
Biochem J. 1958 Mar;68(3):468-75. doi: 10.1042/bj0680468.
3
Ascorbic acid recycling in human neutrophils.人类中性粒细胞中的抗坏血酸循环
J Biol Chem. 1993 Jul 25;268(21):15531-5.
4
Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications.糖尿病与自由基。糖尿病及其并发症病因中的自由基、过渡金属与氧化应激。
Br Med Bull. 1993 Jul;49(3):642-52. doi: 10.1093/oxfordjournals.bmb.a072637.
5
Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro.氨基胍：一种被提议用于糖尿病预防的药物在体外可抑制过氧化氢酶并产生过氧化氢。
Biochem Pharmacol. 1993 Oct 5;46(7):1139-44. doi: 10.1016/0006-2952(93)90461-5.
6
Effects of ethylenediaminetetraacetic acid and 1,10-phenanthroline on cell proliferation and DNA synthesis of Ehrlich ascites cells.
Cancer Res. 1980 Nov;40(11):4092-9.
7
Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.鉴定N-ε-羧甲基赖氨酸为糖化蛋白中果糖赖氨酸的降解产物。
J Biol Chem. 1986 Apr 15;261(11):4889-94.
8
Pro-oxidant activation of ocular reductants. 1. Copper and riboflavin stimulate ascorbate oxidation causing lens epithelial cytotoxicity in vitro.
Exp Eye Res. 1987 Dec;45(6):777-89. doi: 10.1016/s0014-4835(87)80095-7.
9
Ascorbic acid metabolism and polyol pathway in diabetes.糖尿病中的抗坏血酸代谢与多元醇途径
Diabetes. 1989 Feb;38(2):257-61. doi: 10.2337/diab.38.2.257.
10
Reaction of ascorbate with lysine and protein under autoxidizing conditions: formation of N epsilon-(carboxymethyl)lysine by reaction between lysine and products of autoxidation of ascorbate.抗坏血酸盐在自氧化条件下与赖氨酸及蛋白质的反应：赖氨酸与抗坏血酸自氧化产物反应生成Nε-(羧甲基)赖氨酸。
Biochemistry. 1990 Dec 11;29(49):10964-70. doi: 10.1021/bi00501a014.
Zotero 插件