Fialkow P J, Najfeld V, Reddy A L, Singer J, Steinmann L
Lancet. 1978 Aug 26;2(8087):444-6. doi: 10.1016/s0140-6736(78)91444-7.
The glucose-6-phosphate dehydrogenase (G.-6-P.D.) types of isolated blood-cell populations and normal skin were determined in two patients with chronic lymphocytic leukaemia (C.L.L.) who were heterozygous at the G.-6-P.D. locus. Normal tissues from each patient manifested both A and B G.-6-P.D. types, but the C.L.L. B-lymphocyte preparation from one patient showed only a single enzyme type, and from the other patient it showed 95% activity of one G.-6-P.D. type. These observations confirm the supposition based on immunoglobulin-marker data that at the time of study C.L.L. has a clonal origin. In contrast to the B lymphocytes, granulocytes, erythrocytes, platelets, and T lymphocytes displayed both enzyme types in proportions similar to those found in skin. These findings indicate that C.L.L. involves committed B-lymphocyte progenitors. Thus, the disease stands in contrast to chronic myelocytic leukaemia and other myeloproliferative syndromes, all of which involve multipotent haemopoietic stem cells.
测定了两名慢性淋巴细胞白血病（C.L.L.）患者分离的血细胞群体及正常皮肤的葡萄糖-6-磷酸脱氢酶（G.-6-P.D.）类型，这两名患者在G.-6-P.D.位点为杂合子。每名患者的正常组织均表现出A和B两种G.-6-P.D.类型，但其中一名患者的C.L.L. B淋巴细胞制剂仅显示单一酶类型，另一名患者的制剂则显示一种G.-6-P.D.类型的95%活性。这些观察结果证实了基于免疫球蛋白标记数据的推测，即研究时C.L.L.具有克隆起源。与B淋巴细胞不同，粒细胞、红细胞、血小板和T淋巴细胞显示两种酶类型的比例与皮肤中发现的比例相似。这些发现表明C.L.L.涉及定向B淋巴细胞祖细胞。因此，该疾病与慢性粒细胞白血病和其他骨髓增殖性综合征形成对比，后者均涉及多能造血干细胞。
