De Bacquer D, De Henauw S, De Backer G, Kornitzer M
Department of Public Health, University Hospital, University of Gent, Belgium.
Atherosclerosis. 1994 Aug;108(2):193-200. doi: 10.1016/0021-9150(94)90114-7.
To study the association between serum calcium and serum lipids, data from 5394 men and 4800 women in the Belgian Interuniversity Research on Nutrition and Health (25-74 years) were used. By visual inspection of the data a linear increase of both total and HDL cholesterol with serum calcium levels was observed, consistently over all age groups and both sexes. In order to adjust the measured serum calcium concentrations for total serum protein, statistical analyses were performed using Parfitt's correction formula. Multivariate analysis showed in both sexes a highly significant positive association between corrected calcium and total cholesterol independent of age, systolic blood pressure, body mass index, serum uric acid, P/S ratio of diet, cholesterol intake, smoking, educational level and geographical area. The adjusted differences in total cholesterol between the lowest and highest quartile range of the calcium distribution were about 13 mg/dl for both men and women. Protein-corrected calcium was among the strongest correlates with total cholesterol. The analysis of the relation with HDL cholesterol revealed an effect modification by gender. For men no statistically significant correlation between calcium and HDL cholesterol was observed while for women a strong increase of HDL with protein-corrected calcium was found resulting in an adjusted difference of 2.5 mg/dl between the lowest and highest calcium quartile range.
为研究血清钙与血脂之间的关联，我们使用了比利时大学间营养与健康研究（年龄在25至74岁之间）中5394名男性和4800名女性的数据。通过对数据的直观检查，观察到总胆固醇和高密度脂蛋白胆固醇均随血清钙水平呈线性增加，在所有年龄组和两性中均一致。为校正血清总蛋白对测得的血清钙浓度的影响，我们使用帕菲特校正公式进行了统计分析。多变量分析显示，在两性中，校正钙与总胆固醇之间均存在高度显著的正相关，且不受年龄、收缩压、体重指数、血清尿酸、饮食的P/S比值、胆固醇摄入量、吸烟、教育水平和地理区域的影响。钙分布最低和最高四分位数范围之间总胆固醇的校正差异在男性和女性中均约为13mg/dl。蛋白质校正钙是与总胆固醇相关性最强的因素之一。与高密度脂蛋白胆固醇关系的分析显示存在性别效应修饰。在男性中，未观察到钙与高密度脂蛋白胆固醇之间有统计学显著相关性，而在女性中，发现蛋白质校正钙会使高密度脂蛋白显著增加，导致最低和最高钙四分位数范围之间的校正差异为2.5mg/dl。
