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Product inhibition in mechanisms in which the free enzyme isomerizes.在游离酶发生异构化的机制中的产物抑制作用。
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Mathematica program: its use to simulate metabolic irreversible pathways and inhibition of the first enzyme of a pathway by its end product as visualized with the reservoir model.Mathematica 程序:使用该程序通过储库模型模拟代谢不可逆途径和途径中第一个酶被其终产物抑制的情况。
Comput Biol Med. 2013 Aug 1;43(7):853-64. doi: 10.1016/j.compbiomed.2013.04.003. Epub 2013 Apr 18.
3
Kinetics of iso mechanisms.异构机制的动力学
Methods Enzymol. 1995;249:211-40. doi: 10.1016/0076-6879(95)49037-x.
4
Kinetics of enzymes with iso-mechanisms: analysis of product inhibition.具有同工机制的酶的动力学:产物抑制分析
Biochem J. 1993 Dec 1;296 ( Pt 2)(Pt 2):355-60. doi: 10.1042/bj2960355.
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Kinetics of enzymes with iso-mechanisms: analysis and display of progress curves.具有同工机制的酶动力学:进程曲线的分析与展示
Anal Biochem. 1994 Feb 1;216(2):285-90. doi: 10.1006/abio.1994.1043.
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[Trap the product to specifically inhibit the enzyme].捕获该产物以特异性抑制该酶。
Med Sci (Paris). 2007 Dec;23(12):1087-9. doi: 10.1051/medsci/200723121087.
7
Perspectives of data analysis of enzyme inhibition and activation, Part 2: Parametrical classification of types of enzymatic reactions.酶抑制与激活的数据分析视角,第2部分:酶促反应类型的参数分类
J Biochem Mol Toxicol. 2009 Mar-Apr;23(2):101-7. doi: 10.1002/jbt.20272.
8
Identification of enzyme inhibitory mechanisms from steady-state kinetics.从稳态动力学鉴定酶抑制机制。
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Reversible inhibition of enzymatic systems involving covalent intermediates.涉及共价中间体的酶系统的可逆抑制作用。
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10
Combinatorial analysis of multiple substrate-multiple product enzyme reactions.
J Theor Biol. 1972 May;35(2):285-97. doi: 10.1016/0022-5193(72)90040-9.

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Identification of the catalytic mechanism and estimation of kinetic parameters for fumarase.鉴定延胡索酸酶的催化机制并估算其动力学参数。
J Biol Chem. 2011 Jun 17;286(24):21100-9. doi: 10.1074/jbc.M110.214452. Epub 2011 Apr 15.
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Problems in defining limits: how slow is very slow?定义界限的问题:多慢才算非常慢?
Biochem J. 1994 Jul 15;301(Pt 2):623. doi: 10.1042/bj3010623.
3
Isomerization of the free enzyme versus induced fit: effects of steps involving induced fit that bypass enzyme isomerization on flux ratios and countertransport.游离酶的异构化与诱导契合:涉及绕过酶异构化的诱导契合步骤对通量比和逆向转运的影响。
Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):187-99. doi: 10.1042/bj3210187.
4
Flux ratios, induced transport and tracer perturbation.通量比率、诱导转运和示踪剂扰动。
Biochem J. 1994 Sep 15;302 ( Pt 3)(Pt 3):965-6. doi: 10.1042/bj3020965.

本文引用的文献

1
THE PHOSPHOGLUCOMUTASE PATHWAY. AN INVESTIGATION OF PHOSPHO-ENZYME ISOMERIZATION.磷酸葡萄糖变位酶途径。磷酸酶异构化研究。
J Biol Chem. 1964 Nov;239:3935-41.
2
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.具有两种或更多种底物或产物的酶催化反应动力学。I. 命名法和速率方程。
Biochim Biophys Acta. 1963 Jan 8;67:104-37. doi: 10.1016/0006-3002(63)91800-6.
3
Kinetics of enzymes with iso-mechanisms: analysis of product inhibition.具有同工机制的酶的动力学:产物抑制分析
Biochem J. 1993 Dec 1;296 ( Pt 2)(Pt 2):355-60. doi: 10.1042/bj2960355.
4
The concept and use of flux measurements in enzyme studies. A theoretical analysis.酶研究中通量测量的概念与应用。理论分析。
Arch Biochem Biophys. 1966 Oct;117(1):167-83. doi: 10.1016/0003-9861(66)90140-8.
5
The mechanism of the phosphoglucomutase reaction. Studies on rabbit muscle phosphoglucomutase with flux techniques.磷酸葡萄糖变位酶反应的机制。采用通量技术对兔肌肉磷酸葡萄糖变位酶的研究。
Biochem J. 1968 Nov;110(2):161-80. doi: 10.1042/bj1100161.
6
Mechanism of action of 2,3-diphosphoglycerate-independent phosphoglycerate mutase.不依赖2,3-二磷酸甘油酸的磷酸甘油酸变位酶的作用机制。
Biochemistry. 1971 Nov 23;10(24):4522-33. doi: 10.1021/bi00800a028.
7
Mechanism of yeast phosphoglycerate mutase.酵母磷酸甘油酸变位酶的作用机制。
Biochemistry. 1972 Aug 1;11(16):3008-14. doi: 10.1021/bi00766a012.
8
Methods of determining rate constants in single-substrate-single-product enzyme reactions. Use of induced transport: limitations of product inhibition.单底物-单产物酶促反应中速率常数的测定方法。诱导转运的应用:产物抑制的局限性。
Biochem J. 1973 Jun;133(2):255-61. doi: 10.1042/bj1330255.
9
Mechanism of the 2,3-diphosphoglycerate-dependent phosphoglycerate mutase from rabbit muscle.来自兔肌肉的2,3-二磷酸甘油酸依赖性磷酸甘油酸变位酶的作用机制。
Biochem J. 1972 Nov;130(2):397-410. doi: 10.1042/bj1300397.
10
Energetics of enzyme catalysis. I. Isotopic experiments, enzyme interconversion, and oversaturation.
J Theor Biol. 1987 Jan 21;124(2):137-71. doi: 10.1016/s0022-5193(87)80259-x.

Product inhibition in mechanisms in which the free enzyme isomerizes.

作者信息

Cornish-Bouden A

出版信息

Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):621-3. doi: 10.1042/bj3010621.

DOI:10.1042/bj3010621
PMID:7980771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137126/
Abstract
摘要