Aspects of morphogenesis and cytodifferentiation of endoderm offered by organ culture techniques.

In this article, I will summarize the results obtained in my laboratory from the study of organogenesis since 1970. The results have shown region-specific directive influence of mesenchymes and reactivity of endoderms including those of the allantois, yolk sac, digestive tract and urogenital sinus. It was also shown that morphogenesis can take place without coupling cytodifferentiation in heterologous recombination experiments.