Morotomi Y, Todani T, Hosomi H
Department of Pediatric Surgery, Kagawa Medical School, Japan.
Surg Today. 1994;24(8):707-12. doi: 10.1007/BF01636776.
The aim of this study was to define the functional role of the pancreaticoduodenal papilla (PDP) in the regulation of pancreatic outflow into the duodenum in response to feeding and secretin administration in conscious dogs. The canine model we developed allowed for measurement of the pancreatic ductal pressure and pancreatic outflow simultaneously in a physiological state without interfering with the flow of pancreatic juice via the intact sphincter of the duodenal papilla. Feeding increased the pancreatic outflow from 2.8 +/- 0.2 to 13.4 +/- 1.3 ml/15 min with a slight increase in the pancreatic ductal pressure from 8.5 +/- 0.6 to 13.7 +/- 1.4 cmH2O. The administration of secretin increased the pancreatic outflow from 2.8 +/- 0.2 to 12.7 +/- 1.0 ml/15 min without increasing the pancreatic ductal pressure. The viscosity of the pancreatic juice increased during exposure to food, but decreased following food intake and secretin administration, after which the PDP seemed to dilate by about 40% of the fasting value. The results suggest that PDP changes its opening to maintain the pancreatic ductal pressure below a certain level, even if pancreatic secretion into the pancreatic duct increases due to food intake and secretin administration.
本研究的目的是确定在清醒犬中，胰十二指肠乳头（PDP）在进食和给予促胰液素时调节胰腺向十二指肠流出中的功能作用。我们开发的犬模型能够在生理状态下同时测量胰管压力和胰腺流出量，且不会干扰胰液通过十二指肠乳头完整括约肌的流动。进食使胰腺流出量从2.8±0.2增加至13.4±1.3 ml/15分钟，同时胰管压力略有升高，从8.5±0.6升至13.7±1.4 cmH₂O。给予促胰液素使胰腺流出量从2.8±0.2增加至12.7±1.0 ml/15分钟，而胰管压力未升高。在接触食物期间胰液粘度增加，但在进食和给予促胰液素后降低，之后PDP似乎扩张至空腹值的约40%。结果表明，即使由于进食和给予促胰液素导致胰腺向胰管的分泌增加，PDP也会改变其开口以将胰管压力维持在一定水平以下。
