Wagner R, Bonifacio E, Bingley P J, Genovese S, Reinwein D, Bottazzo G F
Department of Immunology, London Hospital Medical College, UK.
Clin Investig. 1994 Jul;72(7):494-8. doi: 10.1007/BF00207476.
Interleukin-2 receptors are released in the circulation in response to antigenic ro mitogenic stimulation of T-lymphocytes. Abnormal serum interleukin-2 receptor levels have been found in young children with type 1 diabetes and "prediabetes." We measured interleukin-2 receptor levels in 17 patients with newly diagnosed type 1 diabetes, 21 patients with long-standing type 1 diabetes, 19 patients with long-standing type 2 diabetes, 19 islet-cell antibody positive nondiabetic polyendocrine patients, 12 islet-cell antibody-positive first-degree relatives of patients with type 1 diabetes and compared the results to age- and sex-matched normal controls. We found significantly lower interleukin-2 receptor levels in patients with newly diagnosed and long-standing type 1 diabetes compared to normal controls (87 +/- 11 and 93 +/- 11 vs. 142 +/- 25 and 132 +/- 40 U/ml, P < 0.001 and P < 0.01). There were no significant differences in interleukin-2 receptor levels between prediabetic groups and normal controls or patients with long-standing type 1 or type 2 diabetes. There was no correlation between glycosylated hemoglobin, blood glucose levels, and interleukin-2 receptor in the groups with long-standing type 1 or type 2 diabetes. We conclude that patients with type 1 diabetes have low interleukin-2 receptor serum levels. This phenomenon is acquired close to disease onset and is unlikely to be an early markers of type 1 diabetes.
白细胞介素-2受体在T淋巴细胞受到抗原性或促有丝分裂刺激后释放到循环中。在1型糖尿病和“糖尿病前期”的幼儿中发现血清白细胞介素-2受体水平异常。我们检测了17例新诊断的1型糖尿病患者、21例长期患1型糖尿病的患者、19例长期患2型糖尿病的患者、19例胰岛细胞抗体阳性的非糖尿病多内分泌患者、12例1型糖尿病患者的胰岛细胞抗体阳性的一级亲属的白细胞介素-2受体水平，并将结果与年龄和性别匹配的正常对照组进行比较。我们发现，与正常对照组相比，新诊断和长期患1型糖尿病的患者白细胞介素-2受体水平显著降低（87±11和93±11 vs. 142±25和132±40 U/ml，P<0.001和P<0.01）。糖尿病前期组与正常对照组之间或长期患1型或2型糖尿病的患者之间白细胞介素-2受体水平无显著差异。在长期患1型或2型糖尿病的组中，糖化血红蛋白、血糖水平与白细胞介素-2受体之间无相关性。我们得出结论，1型糖尿病患者血清白细胞介素-2受体水平较低。这种现象在疾病发病时附近获得，不太可能是1型糖尿病的早期标志物。
