Beard C M, Lane A W, O'Fallon W M, Riggs B L, Melton L J
Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN 55905.
Ann Epidemiol. 1994 Sep;4(5):398-403. doi: 10.1016/1047-2797(94)90075-2.
We attempted to enroll an age-stratified random sample of Rochester, Minnesota women > or = 30 years of age in a population-based prospective study of the determinants of bone loss. Using the resources of the Rochester Epidemiology Project, 541 women were contacted and 305 agreed to participate. Of 236 nonrespondents, 38 were ineligible and 198 refused to participate resulting in a 61% response rate for eligible subjects. We reviewed community medical records for respondents and nonrespondents (including ineligibles) to determine whether the two groups differed with regard to variables that might be important in osteoporosis research. There was little difference between respondents and nonrespondents for a history of cigarette smoking, hyperthyroidism, thyroidectomy, or age-related fractures. Respondents survived better, were less likely to be obese or have renal failure, and more likely to have had an oophorectomy and consume alcohol (P < 0.01). These data suggest that nonrespondents were less healthy than respondents.
我们试图在一项基于人群的骨质流失决定因素前瞻性研究中，纳入明尼苏达州罗切斯特市年龄大于或等于30岁的分层随机抽样女性。利用罗切斯特流行病学项目的资源，联系了541名女性，其中305名同意参与。在236名未回复者中，38名不符合条件，198名拒绝参与，符合条件的受试者回复率为61%。我们查阅了回复者和未回复者（包括不符合条件者）的社区医疗记录，以确定两组在骨质疏松症研究中可能重要的变量方面是否存在差异。在吸烟史、甲状腺功能亢进、甲状腺切除术或与年龄相关的骨折方面，回复者和未回复者之间几乎没有差异。回复者生存状况更好，肥胖或患肾衰竭的可能性较小，且更有可能接受过卵巢切除术并饮酒（P<0.01）。这些数据表明，未回复者的健康状况不如回复者。
