Martínez Cairo Cueto S, Santos Preciado J I, Llorens Cruset C, Cisneros González N
Laboratorio de inmunoquímica y enfermedades infecciosas, Hospital Infantil de México Federico Gómez, México, DF.
Rev Alerg Mex. 1994 Jul-Aug;41(4):103-6.
Tuftsin has the function of activating cellular macrophages and polymorphonuclears (PMNs). This tetrapeptide is transported by the CH2 domain of the heavy chain between residues 289 and 292 of the gammaglobulin (IgG) molecule. The objective of this work is to determine the effect of synthetic tuftsin in its oxidative capacity of PMN cells of newborns of low birth weight for their gestational age having already been demonstrated that the phagocytic activity of these cells of macrophages and PMNs is diminished compared with the cells of newborns of normal birth weight according to gestational age. Results showed a stimulatory effect of the PMNs oxidative capacity with synthetic tuftsin by the increase of the nitrotetrazolium blue reduction, demonstrating that the low oxidative capacity of the cells of newborns of low birth weigh for gestational age does not correlate with an intrinsic cellular defect.
促吞噬素具有激活细胞巨噬细胞和多形核白细胞（PMN）的功能。这种四肽由重链的CH2结构域在γ球蛋白（IgG）分子的289至292位残基之间转运。这项工作的目的是确定合成促吞噬素对低出生体重新生儿的PMN细胞氧化能力的影响，因为已经证明，与根据胎龄正常出生体重的新生儿的细胞相比，这些巨噬细胞和PMN细胞的吞噬活性降低。结果表明，合成促吞噬素通过增加硝基四氮唑蓝还原对PMN氧化能力有刺激作用，表明低出生体重新生儿的细胞对于胎龄的低氧化能力与细胞内在缺陷无关。
