Tang R B, Wu K G, Hwang B
Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Oct;54(4):246-50.
This study was designed to compare the skin testing and in vitro testing for the diagnosis of most common inhalant allergens in asthmatic children.
Sixty-two asthmatic children positive to most common allergens in the area of skin tests and multiple allergosorbent chemiluminescent assay (MAST-CLA) were subjected to another Pharmacia CAP test (CAP).
The agreement between the results of MAST-CLA and CAP was variable. The correlation coefficient for CAP with MAST-CLA was significant for five allergens except candida, dog dander and Willow pollen when the diagnostic levels of MAST-CLA and CAP were compared with skin test reactions. For all the allergens tested, MAST-CLA showed a sensitivity of 51%, a specificity of 84% and an efficiency of 73%, compared with 57%, 80% and 74%, respectively, in the CAP analysis.
MAST-CLA and CAP can be used as a screening test to measure allergen IgE level. Both MAST-CLA and CAP were comparable in their ability to diagnose of allergy to tested allergens.
本研究旨在比较皮肤试验和体外试验在诊断哮喘儿童最常见吸入性过敏原方面的效果。
对62名在皮肤试验和多种变应原吸附化学发光测定法（MAST-CLA）中对该地区最常见过敏原呈阳性反应的哮喘儿童进行另一项法玛西亚CAP试验（CAP）。
MAST-CLA和CAP的结果之间的一致性存在差异。当将MAST-CLA和CAP的诊断水平与皮肤试验反应进行比较时，除念珠菌、狗毛屑和柳树花粉外，CAP与MAST-CLA对五种过敏原的相关系数具有显著性。在所有检测的过敏原中，MAST-CLA的敏感性为51%，特异性为84%，效率为73%，相比之下，CAP分析中的相应数据分别为57%、80%和74%。
MAST-CLA和CAP可作为测量过敏原IgE水平的筛查试验。MAST-CLA和CAP在诊断对检测过敏原的过敏方面能力相当。
