对232例患者进行吸入性过敏性疾病诊断时，针对六种变应原的RAST和MAST-CLA的比较评估。

Comparative evaluation of RAST and MAST-CLA for six allergens for the diagnosis of inhalant allergic disease in 232 patients.

作者信息

Scolozzi R, Vicentini L, Boccafogli A, Camerani A, Pradella R, Cavallini A, Bagni B

机构信息

Service of Allergology and Clinical Immunology, University of Ferrara, Italy.

出版信息

Clin Exp Allergy. 1992 Feb;22(2):227-31. doi: 10.1111/j.1365-2222.1992.tb03077.x.

DOI:10.1111/j.1365-2222.1992.tb03077.x

PMID:1571816

Abstract

The aim of this study was to compare a recent multiple allergosorbent chemiluminescent assay (MAST-CLA) with the RAST for the diagnosis of inhalant allergic disease in 232 patients with rhinitis and/or bronchial asthma. As judged by concordance of clinical history, skin prick tests to a range of six allergens common to our geographic area, and by nasal provocation tests, 70 patients were non-allergic and 162 allergic: 70 to grasses, 46 to mites, four to mugwort, eight to pellitory, and 34 were sensitive to several allergens. In our patient sample that, among other things, comprises subjects with fairly rare monoallergies, MAST-CLA testing gave results which closely corresponded to positive RAST for the allergens studied, and demonstrated a close correlation with the diagnosis of inhalant-specific allergy. Our results showed that, for overall allergens, MAST-CLA was lightly less sensitive and more specific than RAST (the two in vitro tests gave an identical overall efficiency).

摘要

本研究的目的是比较一种最新的多过敏原吸附化学发光分析法（MAST-CLA）与放射性变应原吸附试验（RAST），以诊断232例鼻炎和/或支气管哮喘患者的吸入性过敏性疾病。根据临床病史的一致性、对我们所在地理区域常见的六种过敏原进行的皮肤点刺试验以及鼻激发试验判断，70例患者无过敏反应，162例为过敏：70例对草过敏，46例对螨过敏，4例对艾蒿过敏，8例对墙草过敏，34例对多种过敏原敏感。在我们的患者样本中，除其他情况外，还包括患有相当罕见的单一过敏原过敏的受试者，MAST-CLA检测结果与所研究过敏原的RAST阳性结果密切对应，并显示与吸入性特异性过敏的诊断密切相关。我们的结果表明，对于总体过敏原，MAST-CLA的敏感性略低于RAST，特异性高于RAST（这两种体外试验的总体效率相同）。