Hoppe R T, Hanlon A L, Hanks G E, Owen J B
American College of Radiology, Philadelphia, Pennsylvania.
Cancer. 1994 Dec 15;74(12):3198-203. doi: 10.1002/1097-0142(19941215)74:12<3198::aid-cncr2820741219>3.0.co;2-9.
The prognosis for Hodgkin's disease patients has improved significantly since the early 1960s. The reasons for this improvement are multifactorial.
In the Patterns of Care Study of the American College of Radiology, national surveys to examine process and outcome of patients treated for Hodgkin's disease in 1973 and 1983 were completed. Data were compared for patients who had Stage I-II Hodgkin's disease and who were treated with radiation therapy alone.
Clinical characteristics of the patients in the two different treatment eras were similar. There were important differences in treatment parameters. In 1983 compared with 1973, there was more common use of a dedicated simulator, performance of routine port films, use of linear accelerators, use of individually shaped blocks, and treatment to extended fields. Adequacy of treatment fields also was judged superior in the 1983 study. There were improvements in survival and relapse-free survival for patients treated in 1983 versus 1973.
Improvement in radiation therapy technique is associated with an improved outcome for patients treated for Hodgkin's disease. The national standards have improved during the time from 1973 to 1983.
自20世纪60年代初以来,霍奇金病患者的预后有了显著改善。这种改善的原因是多方面的。
在美国放射学会的治疗模式研究中,完成了对1973年和1983年接受霍奇金病治疗的患者的治疗过程和结果的全国性调查。对患有I-II期霍奇金病且仅接受放射治疗的患者的数据进行了比较。
两个不同治疗时代患者的临床特征相似。治疗参数存在重要差异。与1973年相比,1983年更常使用专用模拟机、进行常规射野片拍摄、使用直线加速器、使用个体化塑形挡块以及对扩大野进行治疗。在1983年的研究中,治疗野的充分性也被判定为更好。与1973年治疗的患者相比,1983年治疗的患者的生存率和无复发生存率有所提高。
放射治疗技术的改进与霍奇金病治疗患者的预后改善相关。从1973年到1983年期间,国家标准有所提高。