Simon G A, Schmid P, Reifenrath W G, van Ravenswaay T, Stuck B E
Israel Institute for Biological Research, Ness-Ziona.
J Pharm Sci. 1994 Aug;83(8):1101-6. doi: 10.1002/jps.2600830807.
The skin of Yorkshire pigs was irradiated with various doses of argon and copper-vapor laser and evaluated for effects on healing time of pretreatment with topical or intramuscular vitamin E or the Op-Site wound dressing. Incident irradiance for both lasers was between 3.5 and 4.5 W/cm2 for a 10-14-mm beam diameter with a nearly uniform intensity profile. Minimal erythemic dose for the copper-vapor laser was 35 +/- 2 J/cm2 (10 s exposure) and 22.4 +/- 0.1 J/cm2 (6-s exposure) for the argon laser. Three dose levels were administered: a low dose causing light erythema, an intermediate dose, and a high dose causing dermal stasis. The radiant exposures for low, intermediate, and high doses were 35, 70, and 138 J/cm2 for the copper-vapor laser and 22.4, 55, and 129 J/cm2 for the argon laser. Exposure to argon and copper-vapor lasers generally caused wounds with similar healing times. Healing time was significantly decreased for wounds caused by intermediate exposure of the copper-vapor laser and either pretreated with vitamin E or treated with the wound dressing. Healing times for corresponding argon-laser exposure were significantly decreased with pretreatment of intramuscular vitamin E only or after treatment with the wound dressing. These findings may be valuable in selecting treatment for accidental laser skin injuries in man.
用不同剂量的氩激光和铜蒸气激光照射约克郡猪的皮肤，并评估局部或肌肉注射维生素E或使用Op-Site伤口敷料预处理对愈合时间的影响。两种激光的入射辐照度在3.5至4.5 W/cm²之间，光束直径为10 - 14毫米，强度分布几乎均匀。铜蒸气激光的最小红斑剂量为35±2 J/cm²（10秒曝光），氩激光为22.4±0.1 J/cm²（6秒曝光）。给予三个剂量水平：低剂量引起轻度红斑，中剂量，高剂量引起皮肤瘀血。铜蒸气激光低、中、高剂量的辐射暴露分别为35、70和138 J/cm²，氩激光分别为22.4、55和129 J/cm²。暴露于氩激光和铜蒸气激光通常会导致伤口愈合时间相似。铜蒸气激光中等剂量照射引起的伤口，经维生素E预处理或使用伤口敷料处理后，愈合时间显著缩短。相应的氩激光照射伤口，仅在肌肉注射维生素E预处理后或使用伤口敷料处理后，愈合时间显著缩短。这些发现对于选择人类意外激光皮肤损伤的治疗方法可能具有重要价值。
