滑膜淋巴细胞表明“细菌”因素可能导致某些类风湿性关节炎病例。
Synovial lymphocytes indicate "bacterial" agents may cause some cases of rheumatoid arthritis.
作者信息
Ford D K, Schulzer M
机构信息
Department of Medicine, University of British Columbia, Vancouver, Canada.
出版信息
J Rheumatol. 1994 Aug;21(8):1447-9.
OBJECTIVE
To evaluate synovial lymphocyte response data from "rheumatoid" patients, to determine if "bacterial" antigens caused significant stimulation.
METHODS
Two-tailed t tests, analysis of variance, and metaanalysis were applied to 3H-thymidine uptake triplicate/quadruplicate counts, resulting from microbiological antigen stimulation of synovial fluid lymphocytes.
RESULTS
In 5 patients with rheumatoid arthritis, maximal synovial lymphocyte responses to chlamydial (in 3) and salmonella (in 2) antigens were significantly greater than to other tested antigens.
CONCLUSION
The data, associated with other published data from similar studies, suggest that Chlamydia and pathogenic Enterobacteriaceae may be etiologically related to the arthritis of some patients with rheumatoid arthritis.
目的
评估“类风湿性”患者的滑膜淋巴细胞反应数据，以确定“细菌”抗原是否引起显著刺激。
方法
对滑膜液淋巴细胞经微生物抗原刺激后的3H-胸腺嘧啶核苷摄取的一式三份/一式四份计数应用双尾t检验、方差分析和荟萃分析。
结果
在5例类风湿性关节炎患者中，滑膜淋巴细胞对衣原体（3例）和沙门氏菌（2例）抗原的最大反应显著大于对其他测试抗原的反应。
结论
这些数据与来自类似研究的其他已发表数据表明，衣原体和致病性肠杆菌科可能在病因上与一些类风湿性关节炎患者的关节炎有关。
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