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两性霉素B衍生物在CD4结合后阻断1型人类免疫缺陷病毒进入：对病毒-细胞融合有影响，但对细胞-细胞融合无影响。

Amphotericin B derivative blocks human immunodeficiency virus type 1 entry after CD4 binding: effect on virus-cell fusion but not on cell-cell fusion.

作者信息

Pleskoff O, Seman M, Alizon M

机构信息

INSERM U.332, Institut Cochin de Génétique Moléculaire, Paris, France.

出版信息

J Virol. 1995 Jan;69(1):570-4. doi: 10.1128/JVI.69.1.570-574.1995.

DOI:10.1128/JVI.69.1.570-574.1995
PMID:7983757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188612/
Abstract

The antiviral effect of MS8209, an amphotericin B derivative, was studied in CD4+ cells transfected with a lacZ gene inducible upon human immunodeficiency virus type 1 (HIV-1) infection. MS8209 was shown to block virus entry after receptor binding and probably before virus-cell membrane fusion, but it had no effect on syncytium formation, although both processes are mediated by HIV-1 envelope proteins and CD4.

摘要

两性霉素B衍生物MS8209的抗病毒作用在转染了1型人类免疫缺陷病毒（HIV-1）感染时可诱导表达的lacZ基因的CD4 +细胞中进行了研究。结果显示，MS8209在受体结合后、可能在病毒-细胞膜融合之前阻断病毒进入，但对合胞体形成没有影响，尽管这两个过程均由HIV-1包膜蛋白和CD4介导。

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2
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