Hiehle J F, Lenkinski R E, Grossman R I, Dousset V, Ramer K N, Schnall M D, Cohen J A, Gonzalez-Scarano F
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia 19104.
Magn Reson Med. 1994 Sep;32(3):285-93. doi: 10.1002/mrm.1910320303.
Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H-MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of N-acetyl-aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed "marker peaks." The MTR of white matter lesions in the MS patients was markedly decreased (6-34%; normal approximately 42%), and correlated well with increase in the marker peaks region (0.94-3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.
磁化传递成像（MT）和局部质子磁共振波谱（1H-MRS）被用于评估多发性硬化症（MS）患者的病灶（T2加权图像上的高信号异常）和正常外观的白质（NAWM）。11例临床诊断为MS的患者分别接受了1H-MRS和MT检查。将病灶的磁化传递率（MTR）与N-乙酰天门冬氨酸（NAA）的相对浓度以及2.1至2.6 ppm处的复合峰（称为“标记峰”）进行比较。MS患者白质病灶的MTR显著降低（6%-34%；正常约为42%），且与标记峰区域的增加密切相关（0.94-3.89）。NAA的相对浓度与MTR之间无相关性。2.1至2.6 ppm范围内共振峰的增加和MTR的显著降低可能是脱髓鞘的相对特异性指标。
