Bellini A M, Vertuani G, Cavazzini G
Ann Sclavo. 1976 May-Jun;18(3):469-78.
The synthesis of derivatives of dehydro-and deoxy-colic acids with L-lysine and Lysil-lysine with antibacterial activity, is here described. Results show no antibacterial activity of dehydrocolic acid derivatives, while deoxycol-lys-OH-HCl, and particularly deoxycol-lys-NH2-2HCl, seem to be very effective on Gram-positive bacteria at 5 mug/ml, and on Gram-negatives at 25 mug/ml.
本文描述了具有抗菌活性的脱氢胆酸和脱氧胆酸与L-赖氨酸及赖氨酰赖氨酸的衍生物的合成。结果表明，脱氢胆酸衍生物没有抗菌活性，而脱氧胆酸-L-赖氨酸-OH·HCl，特别是脱氧胆酸-L-赖氨酸-NH₂·2HCl，在5微克/毫升时对革兰氏阳性菌似乎非常有效，在25微克/毫升时对革兰氏阴性菌有效。
