Heiskanen K, Salmenperä L, Perheentupa J, Siimes M A
Children's Hospital, University of Helsinki, Finland.
Am J Clin Nutr. 1994 Dec;60(6):907-10. doi: 10.1093/ajcn/60.6.907.
To study the effect of type of feeding on infant vitamin B-6 status, we determined erythrocyte pyridoxal 5'-phosphate concentration (EPLP) and erythrocyte aspartate aminotransferase basal activity (EASTo) and its activation coefficient (alpha EAST) in 109 infants at 2, 4, 6, 9, and 12 mo of age. Thirty-six infants were exclusively breast-fed for 9 mo. Forty-six infants were exclusively breast-fed for 6 mo, and then given solid foods in addition. Twenty-seven infants were weaned by 2-3 mo to an adapted cow milk-based formula (15 g protein/L and 0.6 mg pyridoxine/L) and given solid foods from 3 to 4 mo. Infant vitamin B-6 status was age-dependent; it was highest at 4 mo and thereafter gradually approached adult values. The larger the intake of formula, the higher the vitamin B-6 status. In formula-fed infants at ages 2-6 mo, 71-96% of the EPLP values and 57-70% of the EASTo values were above the 95th percentile, and 35-53% of the alpha EAST values were below the 5th percentile for these values in breast-fed infants. These findings raise the question of whether the vitamin B-6 content of formulas, especially in relation to protein content, should be reduced.
为研究喂养方式对婴儿维生素B-6状态的影响，我们测定了109名2、4、6、9和12月龄婴儿的红细胞磷酸吡哆醛浓度（EPLP）、红细胞天冬氨酸转氨酶基础活性（EASTo）及其激活系数（αEAST）。36名婴儿纯母乳喂养9个月。46名婴儿纯母乳喂养6个月，之后添加固体食物。27名婴儿在2至3个月时断奶，改用适合婴儿的以牛奶为基础的配方奶粉（蛋白质15 g/L，吡哆醇0.6 mg/L），并在3至4个月时添加固体食物。婴儿的维生素B-6状态与年龄有关；4个月时最高，此后逐渐接近成人水平。配方奶粉摄入量越大，维生素B-6状态越高。在2至6月龄的配方奶粉喂养婴儿中，EPLP值的71%至96%和EASTo值的57%至70%高于母乳喂养婴儿这些值的第95百分位数，αEAST值的35%至53%低于母乳喂养婴儿这些值的第5百分位数。这些发现提出了一个问题，即配方奶粉中的维生素B-6含量，尤其是与蛋白质含量相关的部分，是否应该降低。
