Shi-Sheng Zhou, Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, Liaoning Province, China.
World J Diabetes. 2014 Feb 15;5(1):1-13. doi: 10.4239/wjd.v5.i1.1.
Over the past few decades, food fortification and infant formula supplementation with high levels of vitamins have led to a sharp increase in vitamin intake among infants, children and adults. This is followed by a sharp increase in the prevalence of obesity and related diseases, with significant disparities among countries and different groups within a country. It has long been known that B vitamins at doses below their toxicity threshold strongly promote body fat gain. Studies have demonstrated that formulas, which have very high levels of vitamins, significantly promote infant weight gain, especially fat mass gain, a known risk factor for children developing obesity. Furthermore, ecological studies have shown that increased B vitamin consumption is strongly correlated with the prevalence of obesity and diabetes. We therefore hypothesize that excess vitamins may play a causal role in the increased prevalence of obesity. This review will discuss: (1) the causes of increased vitamin intake; (2) the non-monotonic effect of excess vitamin intake on weight and fat gain; and (3) the role of vitamin fortification in obesity disparities among countries and different groups within a country.
在过去的几十年中，食物强化和高剂量维生素配方奶粉的使用导致婴儿、儿童和成年人的维生素摄入量大幅增加。随之而来的是肥胖和相关疾病的患病率急剧上升，在国家和国家内部的不同群体之间存在显著差异。长期以来，人们一直知道，低于毒性阈值的 B 族维生素剂量会强烈促进体脂增加。研究表明，含有非常高维生素水平的配方奶粉会显著促进婴儿体重增加，特别是脂肪量增加，这是儿童肥胖的已知风险因素。此外，生态学研究表明，B 族维生素摄入量的增加与肥胖和糖尿病的患病率密切相关。因此，我们假设过量的维生素可能在肥胖症患病率上升中起因果作用。这篇综述将讨论：（1）维生素摄入量增加的原因；（2）过量维生素摄入对体重和体脂增加的非单调效应；（3）维生素强化在国家间和国家内部不同群体之间肥胖差异中的作用。
