Wahlqvist M L, Wattanapenpaiboon N, Macrae F A, Lambert J R, MacLennan R, Hsu-Hage B H
Department of Medicine, Monash Medical Centre, Monash University, Clayton, Australia.
Am J Clin Nutr. 1994 Dec;60(6):936-43. doi: 10.1093/ajcn/60.6.936.
The effect of beta-carotene supplementation on major serum carotenoid fractions (lutein/zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, and beta-carotene) was investigated in 224 people with colorectal adenomas (139 men, 85 women) recruited for the Australian Polyp Prevention Project (APPP). Each subject was randomly assigned to take either 20 mg beta-carotene/d or placebo over 24 mo. Besides the expected increase in serum concentration of beta-carotene (1073% in men, 839% in women), lycopene (176% in men) and alpha-carotene (211% in men and 166% in women) concentrations were also increased after body mass index, baseline concentration, change in respective carotenoid intake, and other confounding factors were adjusted for. The increase in serum concentrations of these carotenoids after beta-carotene supplementation suggests that beta-carotene may interact biologically with other carotenoids and such interaction would need to be taken into consideration when the protective effect of beta-carotene supplementation for cancer or other diseases is examined.
在澳大利亚息肉预防项目（APPP）招募的224例结直肠腺瘤患者（139例男性，85例女性）中，研究了补充β-胡萝卜素对主要血清类胡萝卜素组分（叶黄素/玉米黄质、β-隐黄质、番茄红素、α-胡萝卜素和β-胡萝卜素）的影响。每位受试者被随机分配服用20毫克β-胡萝卜素/天或安慰剂，持续24个月。除了血清β-胡萝卜素浓度预期增加外（男性增加1073%，女性增加839%），在调整体重指数、基线浓度、各胡萝卜素摄入量变化及其他混杂因素后，番茄红素（男性增加176%）和α-胡萝卜素（男性增加211%，女性增加166%）浓度也有所增加。补充β-胡萝卜素后这些类胡萝卜素血清浓度的增加表明，β-胡萝卜素可能与其他类胡萝卜素有生物学相互作用，在研究补充β-胡萝卜素对癌症或其他疾病的保护作用时，需要考虑这种相互作用。
