Shin Y C, Han D K, Kim Y H, Kim S C
Department of Chemical Engineering, Korea Advanced Institute of Science and Technology, Taejon.
J Biomater Sci Polym Ed. 1994;6(3):281-95. doi: 10.1163/156856294x00365.
To investigate the effect of hydrophilic and hydrophobic surfaces with phase separated structure on their blood responses, interpenetrating polymer networks (IPNs) composed of hydrophilic polyurethane (PU) and hydrophobic polystyrene (PS) were prepared by simultaneous polymerization. In vitro protein adsorption, in vitro platelet adhesion, and ex vivo A-A shunt test were carried out to evaluate the blood compatibility of the PU/PS IPNs. The results of protein adsorption on the PU/PS IPN surfaces indicated that albumin preferentially adsorbed on the hydrophilic surface (PU), while fibrinogen preferentially adsorbed on the hydrophobic surface (PS). The PU/PS IPNs exhibited suppressive properties for both platelet adhesion and activation. The occlusion time of U50S50 IPN containing 50 wt% of PS was twice as long as that of the PU control (50 min), indicating enhanced blood compatibility, presumably due to the selective adsorption of plasma proteins and the suppression of the adhesion and activation of platelets.
为了研究具有相分离结构的亲水性和疏水性表面对其血液反应的影响，通过同步聚合制备了由亲水性聚氨酯（PU）和疏水性聚苯乙烯（PS）组成的互穿聚合物网络（IPN）。进行了体外蛋白质吸附、体外血小板粘附和离体A - A分流试验，以评估PU/PS IPN的血液相容性。PU/PS IPN表面的蛋白质吸附结果表明，白蛋白优先吸附在亲水性表面（PU）上，而纤维蛋白原优先吸附在疏水性表面（PS）上。PU/PS IPN对血小板粘附和活化均表现出抑制特性。含有50 wt% PS的U50S50 IPN的闭塞时间是PU对照（50分钟）的两倍，表明血液相容性增强，这可能是由于血浆蛋白的选择性吸附以及血小板粘附和活化的抑制。
