Kim J H, Kim S C
Center for Advanced Functional Polymers, Korea Advanced Institute of Science and Technology, Taejon, South Korea.
Biomaterials. 2002 May;23(9):2015-25. doi: 10.1016/s0142-9612(01)00330-1.
Polyurethane (PU) homopolymers and PU/polystyrene (PS) interpenetrating polymer networks (IPNs) were successfully synthesized changing the length of the pendant poly(ethylene oxide) (PEO) chains and the grafting density of PEO chains. All the PU/PS IPNs had the microphase-separated structures in which the PS-rich phase domains were dispersed in the matrix of the PU-rich phase. The domain size decreased a little, as the degree of grafting with PEO chains was increased. The water swelling ratio increased, and the interfacial energy decreased, as the length of the pendant PEO chains, and the grafting density of PEO chains of the PEO-grafted PU/PS IPNs were increased, since the mobile hydrophilic pendant PEO chains effectively induced and absorbed the water, when they were contacted with water. The hydrophilic and highly concentrated pendant PEO chains could easily prohibit the adhesion of the fibrinogens and the platelets on the surface, and the blood compatibility of IPNs was enhanced by increasing of grafting with PEO chains. The adsorption of the fibrinogens and the platelets was suppressed, as the length of pendant PEO chains, and the grafting density were increased.
通过改变侧链聚环氧乙烷（PEO）链的长度和PEO链的接枝密度，成功合成了聚氨酯（PU）均聚物和PU/聚苯乙烯（PS）互穿聚合物网络（IPN）。所有的PU/PS IPN都具有微相分离结构，其中富含PS的相域分散在富含PU的相基质中。随着PEO链接枝度的增加，域尺寸略有减小。对于PEO接枝的PU/PS IPN，随着侧链PEO链的长度和PEO链的接枝密度增加，水溶胀率增加，界面能降低，因为当移动的亲水性侧链PEO链与水接触时，它们能有效地诱导并吸收水分。亲水性且高度集中 的侧链PEO链能够轻易地阻止纤维蛋白原和血小板在表面上的粘附通过增加PEO链的接枝，IPN的血液相容性得到增强。随着侧链PEO链的长度和接枝密度增加，纤维蛋白原和血小板的吸附受到抑制。
