Feychting M, Ahlbom A
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Epidemiology. 1994 Sep;5(5):501-9.
We conducted a case-control study to test the hypothesis that exposure to magnetic fields of the type generated by high-voltage power lines increases the incidence of leukemia and central nervous system tumors in adults. The study was based on people who, between 1960 and 1985, had lived on a property in Sweden located within 300 meters of 220 or 400 kilovolt power lines. We identified a total of 325 leukemia cases and 223 cases of central nervous system tumor. Two matched controls per case were selected at random. We assessed exposure by spot measurements and by calculations of the magnetic fields generated by the power lines. For calculated magnetic field levels of 0.2 microT or more closest in time to diagnosis, we found an elevated relative risk (RR) for acute myeloid leukemia [RR = 1.7; 95% confidence interval (CI) = 0.8-3.5] and chronic myeloid leukemia [RR = 1.7; 95% CI = 0.7-3.8]. Using cumulative exposure for the 15 years preceding diagnosis, we found relative risk estimates for acute and chronic myeloid leukemia of 2.3 (95% CI = 1.0-4.6) and 2.1 (95% CI = 0.9-4.7), respectively, for the highest exposure category. For chronic lymphatic leukemia and for central nervous system tumors, relative risk estimates were close to or below unity.
我们开展了一项病例对照研究，以检验以下假设：暴露于高压电线产生的那种磁场会增加成年人患白血病和中枢神经系统肿瘤的风险。该研究基于1960年至1985年间居住在瑞典一处距离220千伏或400千伏电线300米以内房产中的人群。我们共识别出325例白血病病例和223例中枢神经系统肿瘤病例。为每个病例随机选取两名匹配对照。我们通过现场测量以及计算电线产生的磁场来评估暴露情况。对于在最接近诊断时间时计算得出的磁场水平为0.2微特斯拉或更高的情况，我们发现急性髓细胞白血病的相对风险（RR）升高了[RR = 1.7；95%置信区间（CI）= 0.8 - 3.5]，慢性髓细胞白血病也是如此[RR = 1.7；95% CI = 0.7 - 3.8]。使用诊断前15年的累积暴露数据，我们发现最高暴露类别的急性和慢性髓细胞白血病的相对风险估计值分别为2.3（95% CI = 1.0 - 4.6）和2.1（95% CI = 0.9 - 4.
