细胞因子、前列腺素和脂皮质蛋白-1存在于感染瘙痒病的小鼠大脑中。

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice.

作者信息

Williams A E, van Dam A M, Man-A-Hing W K, Berkenbosch F, Eikelenboom P, Fraser H

机构信息

BBSRC and MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, UK.

出版信息

Brain Res. 1994 Aug 22;654(2):200-6. doi: 10.1016/0006-8993(94)90480-4.

DOI:10.1016/0006-8993(94)90480-4

PMID:7987669

Abstract

The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E2, prostaglandin F2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

摘要

在两种羊瘙痒病模型中，对终末期发病小鼠体内的细胞因子、前列腺素和脂皮质蛋白-1进行了研究。在大脑中出现羊瘙痒病特征性空泡化的区域，胶质白细胞介素-1β、肿瘤坏死因子α、前列腺素E2、前列腺素F2α和脂皮质蛋白-1的免疫反应性显著增强。将这些染色模式与GFAP和F4/80的染色模式进行比较，结果表明它们的表达主要发生在星形胶质细胞中。细胞因子可能在羊瘙痒病神经退行性变的发病机制中起重要作用。