Research Centre for Encephalopathies and Transmissible Emerging Diseases, Institute for Health Research Aragón (IIS), University of Zaragoza, C/Miguel Servet 155, 50013 Zaragoza, Spain.
Departamento de Patologíay Terapéutica Experimental, Universidad de Barcelona, 08907 Barcelona, Spain.
Biomolecules. 2021 Feb 2;11(2):204. doi: 10.3390/biom11020204.
The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Additionally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.
朊病毒蛋白诱导的神经胶质细胞激活及其随后的细胞因子分泌在朊病毒病中的实际作用仍不完全清楚。本研究的总体目的是评估用地塞米松进行抗炎治疗对天然瘙痒病中可能与神经炎症相关的神经胶质细胞释放的不同细胞因子的影响。本研究强调了几种多功能神经调节剂肽之间存在的复杂相互作用，并提供了一种全面的方法来阐明朊病毒病中的神经炎症过程。此外，还提示细胞因子（主要是 IL-1）介导的小胶质细胞和星形胶质细胞群体之间的通讯障碍。本研究的主要新颖之处在于，它是第一个评估与慢性抗炎治疗相关的原位神经炎症活性的研究，这具有相关性，因为它基于天然模型。细胞因子谱数据表明，一些与神经毒性相关的途径被激活。因此，针对该途径可能是一种改变神经炎症破坏性影响的新方法。
