Gordijn M C, Beersma D G, Bouhuys A L, Reinink E, Van den Hoofdakker R H
Department of Biological Psychiatry, University Clinic, Groningen, The Netherlands.
J Affect Disord. 1994 Aug;31(4):261-73. doi: 10.1016/0165-0327(94)90102-3.
The course of 39 depressed in-patients' daily mood was recorded by means of frequent self-ratings during their entire stay (in total 3718 days). The frequency of diurnal variations largely varies between subjects without clear dichotomy in 'diurnal' and 'non-diurnal' subjects and the occurrence of diurnal variations is rather irregular. Mood variability measures rather than average daily mood improvement correlate with the response to sleep deprivation. These observations do not support theories of chronobiological rhythm disturbances in depression. It is argued that depressed subjects largely vary in susceptibility to stimuli. Signals generated by the biological clock or by processes related to the sleep-wake cycle are considered examples of such stimuli.
通过在39名抑郁症住院患者的整个住院期间（共3718天）频繁进行自我评分，记录了他们每日的情绪变化过程。昼夜变化的频率在个体之间差异很大，在“昼夜型”和“非昼夜型”个体之间没有明显的二分法，而且昼夜变化的发生相当不规律。情绪变异性指标而非每日平均情绪改善情况与睡眠剥夺反应相关。这些观察结果不支持抑郁症存在生物钟节律紊乱的理论。有人认为，抑郁症患者对刺激的易感性差异很大。生物钟或与睡眠-觉醒周期相关的过程产生的信号被认为是此类刺激的例子。
