Hinerman R W, Parsons J T, Mendenhall W M, Stringer S P, Cassisi N J, Million R R
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32610-0385.
Laryngoscope. 1994 Dec;104(12):1466-70. doi: 10.1288/00005537-199412000-00007.
From 1964 to 1990, 134 patients were treated at the University of Florida with continuous-course external beam irradiation, alone or followed by a planned neck dissection, for T1 (n = 17), T2 (n = 47), T3 (n = 49), or T4 (n = 21) carcinoma of the base of tongue. The 5-year rate of local control was 90% for stage T1, 92% for T2, 73% for T3, and 35% for T4. Probability of control above the clavicles at 5 years according to modified American Joint Committee on Cancer (AJCC) stage was 100% for stages I and II, 75% for stage III, 84% for stage IVa, and 52% for stage IVb. Probability of relapse-free survival at 5 years was 100% for stages I and II, 68% for stage III, 81% for stage IVa, and 37% for stage IVb. Severe complications occurred in 2% of patients. Compared with surgical resection of the primary tumor, external beam radiotherapy results in similar rates of local control and survival with a lower risk of severe complications.
1964年至1990年期间，佛罗里达大学对134例舌根部T1期（n = 17）、T2期（n = 47）、T3期（n = 49）或T4期（n = 21）癌患者进行了连续疗程的外照射治疗，单独放疗或随后进行计划性颈部清扫术。T1期的5年局部控制率为90%，T2期为92%，T3期为73%，T4期为35%。根据美国癌症联合委员会（AJCC）修订分期，5年时锁骨上控制概率在I期和II期为100%，III期为75%，IVa期为84%，IVb期为52%。5年无复发生存概率在I期和II期为100%，III期为68%，IVa期为81%，IVb期为37%。2%的患者出现严重并发症。与原发肿瘤手术切除相比，外照射放疗的局部控制率和生存率相似，但严重并发症风险较低。
