Hardt N S, Yu L T, La Torre G, Steinbach B
Department of Pathology, University of Florida, Gainesville.
Mod Pathol. 1994 Aug;7(6):669-76.
Clinically useful methods to identify and document the presence of foreign material in tissues surrounding breast implants are needed. Fourier transform infrared microspectroscopy is an ideal technique for examining tissue for the presence of implantable biomaterials. Because the spectroscopy is microscopically guided, the pathologist is assured that the obtained spectrum is from the region of interest in a tissue section. Scanning electron microscopy yields elemental data but cannot be used to identify compounds. Because each compound has a unique spectrum by Fourier transform infrared microspectroscopy, the spectrum obtained enables identification of the various foreign materials observed by light microscopy in tissues surrounding breast implants. Histopathology from implant capsules demonstrating a silicone gel-filled implant, a saline-filled textured implant, a polyurethane foam-covered gel-filled implant, a Dacron fixation patch, and a paraffin injection granuloma are presented with corresponding Fourier transform infrared microspectroscopy spectra.
需要有临床实用的方法来识别和记录乳房植入物周围组织中异物的存在。傅里叶变换红外显微光谱法是检查组织中是否存在可植入生物材料的理想技术。由于该光谱法是在显微镜引导下进行的，病理学家可以确定所获得的光谱来自组织切片中的感兴趣区域。扫描电子显微镜可产生元素数据，但不能用于识别化合物。由于每种化合物通过傅里叶变换红外光谱法都有独特的光谱，因此所获得的光谱能够识别在乳房植入物周围组织中通过光学显微镜观察到的各种异物。本文展示了植入物包膜的组织病理学情况，包括硅胶填充植入物、盐水填充带纹理植入物、聚氨酯泡沫覆盖的凝胶填充植入物、涤纶固定贴片和石蜡注射性肉芽肿，并给出了相应的傅里叶变换红外光谱。
