Silverstein M L, Harrow M, Bryson G J
Long Island University, Dept. of Psychology, Brookville, NY 11548.
Psychiatry Res. 1994 Jun;52(3):265-72. doi: 10.1016/0165-1781(94)90072-8.
This report examines prognostic implications of neuropsychological deficit for clinical symptomatic improvement. Neuropsychological performance levels are related to the Brief Psychiatric Rating Scale thinking disturbance, paranoid disturbance, withdrawal/retardation, and anxiety/depression scales at hospital admission and discharge in 68 schizophrenic and psychotic and nonpsychotic mood disorder patients. Findings indicate a relationship between neurocognitive deficit and thinking disturbance at admission; however, neuropsychological impairment predicts blunted affect/emotional withdrawal at discharge, after the acute psychopathology resolves. Neuropsychological deficit is nonspecific, occurring across a broad range of cognitive-perceptual functions. These data suggest that neuropsychological dysfunction may be prognostic of a more chronic residual disorder in both schizophrenia and major psychotic and nonpsychotic mood disorder syndromes.
本报告探讨神经心理缺陷对临床症状改善的预后影响。在68例精神分裂症、精神性和非精神性心境障碍患者入院和出院时，神经心理表现水平与简明精神病评定量表的思维紊乱、偏执障碍、退缩/迟缓及焦虑/抑郁量表相关。研究结果表明，入院时神经认知缺陷与思维紊乱之间存在关联；然而，在急性精神病理学症状缓解后，神经心理损害可预测出院时情感迟钝/情绪退缩。神经心理缺陷是非特异性的，广泛存在于各种认知-感知功能中。这些数据表明，神经心理功能障碍可能是精神分裂症、主要精神性和非精神性心境障碍综合征中更慢性残留障碍的预后指标。
