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磁共振图像中白质与大脑皮层边界的分形分析:对精神分裂症和躁郁症患者的对照研究

Fractal analysis of the boundary between white matter and cerebral cortex in magnetic resonance images: a controlled study of schizophrenic and manic-depressive patients.

作者信息

Bullmore E, Brammer M, Harvey I, Persaud R, Murray R, Ron M

机构信息

Institute of Psychiatry, London.

出版信息

Psychol Med. 1994 Aug;24(3):771-81. doi: 10.1017/s0033291700027926.

Abstract

This paper reports development of a computerized ('box-counting') method for estimation of fractal dimension (FD) of the magnetic resonance image (MRI) boundary between cerebral cortex and white matter; and the application of this method to MRIs of 39 schizophrenics (SZs), 23 manic-depressives (MDs) and 31 controls (CONs). Mean FD across all diagnostic groups was 1.402; 95% confidence interval (CI) 1.399 to 1.406. Mean FD was greater in boundaries extracted from manic-depressive patients than in boundaries extracted from controls (difference between MD and CON mean FDs = 0.008; 95% CI -0.002 to +0.018); and less in schizophrenics than in controls (difference between SZ and CON mean FDs = -0.003; 95% CI -0.011 to +0.005). Mean FD was positively correlated with subcortical volume and anterior cerebral volume, and negatively correlated with sulcal cerebrospinal fluid volume. Significant differences in mean FD between diagnostic groups were demonstrated by analysis of covariance (ANCOVA; P < 0.01), with age and volumetric measures of brain size as covariates; and manic-depressive boundaries were shown to have significantly greater values for residual FD (after controlling for effects of brain size) than boundaries extracted from controls (t test; P < 0.05). It is proposed that FD is a useful measure of clinically relevant differences in the complexity of MRI boundaries.

摘要

本文报告了一种用于估计大脑皮层与白质之间磁共振图像(MRI)边界分形维数(FD)的计算机化(“盒计数”)方法的开发;以及该方法在39例精神分裂症患者(SZs)、23例躁郁症患者(MDs)和31例对照者(CONs)的MRI中的应用。所有诊断组的平均FD为1.402;95%置信区间(CI)为1.399至1.406。从躁郁症患者提取的边界的平均FD大于从对照者提取的边界(MD和CON平均FD之差 = 0.008;95% CI为 -0.002至 +0.018);而精神分裂症患者的平均FD小于对照者(SZ和CON平均FD之差 = -0.003;95% CI为 -0.011至 +0.005)。平均FD与皮层下体积和大脑前叶体积呈正相关,与脑沟脑脊液体积呈负相关。通过协方差分析(ANCOVA;P < 0.01),以年龄和脑大小的体积测量值作为协变量,证明了诊断组之间平均FD存在显著差异;并且显示躁郁症边界的残余FD(在控制脑大小的影响后)的值显著大于从对照者提取的边界(t检验;P < 0.05)。有人提出,FD是衡量MRI边界复杂性临床相关差异的有用指标。

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