Lopez D M, Elitsur Y
Department of Pediatrics, Marshall University School of Medicine, Huntington.
W V Med J. 1994 Sep;90(9):367-9.
Helicobacter pylori (HP) is a newly discovered pathogen implicated in the pathophysiology of peptic ulcer disease. The aim of this study was to review all pediatric patients who were evaluated by upper endoscopy through the Pediatric Gastroenterology Service at the Marshall University School of Medicine between July 1990 and March 1993. A total of 100 charts were retrospectively reviewed. HP was diagnosed by CLO-test and confirmed histologically. Results showed that the major presenting symptom was abdominal pain (53%). GI mucosal inflammation was found in 77 patients, and 41% of these cases were associated with HP. Two patients had duodenal ulcer; both were HP+. The incidence of gastritis was significantly higher in patients with HP+ compared to HP-. Follow-up on the HP-associated gastritis showed no significant difference in their clinical response irrespective to the treatment, we conclude that HP in children is highly associated with gastritis, but not duodenitis or esophagitis; and in our experience, that CLO has a high failure rate in identifying HP in the mucosa.
幽门螺杆菌（HP）是一种新发现的与消化性溃疡病病理生理学相关的病原体。本研究的目的是回顾1990年7月至1993年3月期间在马歇尔大学医学院儿科胃肠病科接受上消化道内镜检查评估的所有儿科患者。总共回顾了100份病历。通过CLO试验诊断HP，并经组织学证实。结果显示，主要症状为腹痛（53%）。77例患者发现胃肠道黏膜炎症，其中41%的病例与HP有关。2例患者患有十二指肠溃疡；均为HP阳性。与HP阴性患者相比，HP阳性患者的胃炎发病率显著更高。对HP相关性胃炎的随访显示，无论治疗如何，其临床反应无显著差异，我们得出结论，儿童HP与胃炎高度相关，但与十二指肠炎或食管炎无关；根据我们的经验，CLO在识别黏膜中的HP方面有很高的失败率。
