Romero P A, Athanassiadis A, Lussier M, Herscovics A
McGill Cancer Centre, McGill University, Montréal, Québec, Canada.
Yeast. 1994 Aug;10(8):1111-5. doi: 10.1002/yea.320100813.
The DNA sequence of a 2967 bp fragment located near the centromere of chromosome II, between the CEN2 and FUR4 genes, was determined. The segment contains a new open reading frame of 1794 bp. The product encoded by the gene, designated TTP1, is a predicted type II membrane protein of 597 amino acid residues with a short cytoplasmic NH2-terminus, a membrane-spanning region and a large COOH-terminal region containing three potential N-glycosylation sites. Gene disruption indicated that TTP1 is not essential for cell growth.
测定了位于第二条染色体着丝粒附近、CEN2和FUR4基因之间一个2967 bp片段的DNA序列。该片段包含一个1794 bp的新开放阅读框。该基因编码的产物命名为TTP1，是一种预测的II型膜蛋白，有597个氨基酸残基，其NH2端细胞质区域较短，有一个跨膜区和一个较大的COOH端区域，包含三个潜在的N-糖基化位点。基因敲除表明TTP1对细胞生长不是必需的。
