Astrup A, Buemann B, Western P, Toubro S, Raben A, Christensen N J
Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Am J Clin Nutr. 1994 Feb;59(2):350-5. doi: 10.1093/ajcn/59.2.350.
Expansion of the fat stores has been proposed as a prerequisite for increasing fat oxidation in response to a high-fat diet in individuals with a predisposition to obesity. In a cross-sectional design we measured 24-h substrate oxidations on a standardized diet in 38 overweight or obese and 35 nonobese women. Fat oxidation (g/d) was mainly a function of total energy requirements (r = 0.71, P < 0.0001). To account for this we used for further analysis oxidative fat energy (%), a counterpart to dietary fat energy (%). After differences in fat energy of consumed food (%), age, and 24-h energy balance were adjusted for, obese women had higher oxidative fat energy than did nonobese women [40.2% (37.8-42.6) vs 36.0% (33.6-38.5), P < 0.02]. Adjusted oxidative fat energy (%) increased with increasing size of fat mass (r = 0.31, P < 0.01). This relation suggests that a 10-kg change in fat mass may be caused by a change in dietary fat energy of > or = 1.6% (0.4-2.7%). The study supports the concept that in susceptible individuals the expansion of fat stores is a prerequisite to increase the oxidative fat energy to an amount commensurate with a high percentage of dietary fat energy.
对于易肥胖个体而言，脂肪储备的增加被认为是对高脂饮食做出反应从而增加脂肪氧化的一个先决条件。在一项横断面设计中，我们测量了38名超重或肥胖女性和35名非肥胖女性在标准化饮食下的24小时底物氧化情况。脂肪氧化（克/天）主要是总能量需求的函数（r = 0.71，P < 0.0001）。为了对此进行考量，我们在进一步分析中使用了氧化脂肪能量百分比，它相当于膳食脂肪能量百分比。在对所摄入食物的脂肪能量百分比、年龄和24小时能量平衡的差异进行调整后，肥胖女性的氧化脂肪能量高于非肥胖女性[40.2%（37.8 - 42.6）对36.0%（33.6 - 38.5），P < 0.02]。调整后的氧化脂肪能量百分比随着脂肪量的增加而增加（r = 0.31，P < 0.01）。这种关系表明，脂肪量10千克的变化可能是由膳食脂肪能量变化≥1.6%（0.4 - 2.7%）所导致的。该研究支持了这样一个概念，即在易感个体中，脂肪储备的增加是将氧化脂肪能量提高到与高百分比膳食脂肪能量相称水平的一个先决条件。
