Murray M J
Marion duPont Scott Equine Medical Center, Leesburg, Virginia 22075.
Dig Dis Sci. 1994 Dec;39(12):2530-5. doi: 10.1007/BF02087686.
Ulceration of the gastric squamous epithelial mucosa was induced in 10 horses using a feeding protocol previously shown to expose the gastric mucosa to repeated periods of high acidity. The feeding protocol consisted of alternating feed deprivation with free access to hay. Over a period of seven days, each horse was provided hay for 84 hr and deprived of hay for 84 hr. Hay was never withheld for longer than 24 hr at a time. Gastroscopy was performed on each horse at the beginning of the protocol after 12 hr of feed deprivation, and after a total of 36 hr, 60 hr, and 84 hr of feed deprivation. All horses had normal esophageal and gastric mucosa at the beginning of the protocol. Alternating periods of feeding and feed deprivation resulted in progressive ulceration of the gastric squamous epithelial mucosa in all but one of the horses. Lesions progressed from erosions to ulceration within 36-72 hr of feed deprivation, and by 84 hr of feed deprivation ulcers had developed thickened, raised margins. Esophageal mucosa appeared normal in all horses throughout the study. The protocol of alternating feeding with feed deprivation in horses consistently produced gastric squamous epithelial ulceration and provided a useful model for characterizing temporal transitions in peptic-injured alimentary squamous epithelia.
采用先前已证明能使胃黏膜反复暴露于高酸度环境的饲养方案，在10匹马身上诱发了胃鳞状上皮黏膜溃疡。该饲养方案包括交替进行禁食和自由采食干草。在七天的时间里，每匹马有84小时可自由采食干草，另外84小时禁食。每次禁食时间从不超过24小时。在方案开始时，禁食12小时后、总共禁食36小时、60小时和84小时后，对每匹马进行了胃镜检查。在方案开始时，所有马匹的食管和胃黏膜均正常。除一匹马外，交替进行采食和禁食导致所有马匹的胃鳞状上皮黏膜逐渐出现溃疡。在禁食36 - 72小时内，病变从糜烂发展为溃疡，到禁食84小时时，溃疡边缘增厚、隆起。在整个研究过程中，所有马匹的食管黏膜均正常。马匹交替进行采食和禁食的方案持续产生胃鳞状上皮溃疡，为表征消化性损伤的消化道鳞状上皮的时间转变提供了一个有用的模型。
