Thompson D G
Hope Hospital, Salford, U.K.
Dig Dis Sci. 1994 Dec;39(12 Suppl):48S-50S. doi: 10.1007/BF02300370.
Gastric function is controlled by central and peripheral modulation. Most often, afferent information from the stomach does not reach conscious level. At extremes of chemical and mechanical stimulation, however, afferent signals are perceived as pain. Whether or not a signal is perceived depends on gating of afferent signals at the levels of both spinal cord and brainstem. Inhibition of gastric tone and peristalsis during perceived discomfort largely results from stimulation via sympathetic neural pathways. These findings may be clinically relevant because upper gastrointestinal symptoms in many dyspeptic patients could be the result of primary afferent neuron dysfunction rather than motor dysfunction.
胃功能受中枢和外周调节控制。大多数情况下，来自胃部的传入信息不会到达意识层面。然而，在化学和机械刺激达到极端时，传入信号会被感知为疼痛。一个信号是否被感知取决于脊髓和脑干水平上传入信号的闸门控制。在感觉到不适时胃张力和蠕动的抑制主要是通过交感神经通路的刺激导致的。这些发现可能具有临床相关性，因为许多消化不良患者的上消化道症状可能是初级传入神经元功能障碍而非运动功能障碍的结果。
