Dohmae K, Okabe M, Nishimune Y
Research Institute for Microbial Diseases, Osaka University, Japan.
J Infect Dis. 1994 Dec;170(6):1589-92. doi: 10.1093/infdis/170.6.1589.
This study found a competent transmission of hantavirus between cagemates using congenitally T cell-deficient Rowett nude rats (rnu/rnu). Intraperitoneally infected immunologically normal rats (rnu/+) did not transmit the hantavirus to their normal cagemates (rnu/+) but did to Rowett nude rats (rnu/rnu). Thus, nude rats were shown to be highly susceptible to the hantavirus infection. Also, infected nude rats (rnu/rnu) discharged the infectious viruses, to cause a prevalence of infection among normal cagemates (rnu/+). The infection system demonstrated here using Rowett rats (rnu/rnu) may provide a useful model to study the mechanism of the hantavirus infection.
本研究发现，使用先天性T细胞缺陷的罗威特裸鼠（rnu/rnu），汉坦病毒可在同笼饲养的裸鼠之间有效传播。经腹腔感染的免疫正常大鼠（rnu/+）不会将汉坦病毒传播给其正常的同笼饲养大鼠（rnu/+），但会传播给罗威特裸鼠（rnu/rnu）。因此，裸鼠被证明对汉坦病毒感染高度易感。此外，受感染的裸鼠（rnu/rnu）排出传染性病毒，导致正常同笼饲养大鼠（rnu/+）中出现感染流行。这里使用罗威特大鼠（rnu/rnu）展示的感染系统可能为研究汉坦病毒感染机制提供一个有用的模型。
