Yoshikawa J, Matsui O, Kadoya M, Gabata T, Miyayama S, Takahashi S, Takashima T, Kobayashi K
Department of Radiology, Kanazawa University School of Medicine, Ishikawa-Ken, Japan.
Radiology. 1995 Jan;194(1):107-11. doi: 10.1148/radiology.194.1.7997535.
To evaluate the changes in surrounding liver parenchyma after treatment of hepatocellular carcinoma (HCC) and borderline malignant lesions with percutaneous ethanol injection (PEI).
The authors reviewed the findings at computed tomography (CT) and CT during arterial portography (CTAP) obtained before and after PEI therapy for 32 lesions in 26 patients with HCC or adenomatous hyperplasia. Two surgically resected specimens were also histologically examined.
In 10 (77%) of 13 lesions, decreased portal vein-related enhancement indicative of reduced portal blood flow in the periphery of the tumor was found at CTAP. Mild atrophy (concave liver surface), segmental atrophy, and lobar atrophy were found in 40%, 17%, and 3%, respectively. Histologic examination of the resected specimens revealed organized thrombi in the peripheral portal vein in the surrounding liver.
PEI may cause decreased portal blood flow and atrophy in the noncancerous liver parenchyma that surrounds the tumor being treated.
评估经皮乙醇注射（PEI）治疗肝细胞癌（HCC）及交界性恶性病变后周围肝实质的变化。
作者回顾了26例HCC或腺瘤样增生患者32个病变在PEI治疗前后的计算机断层扫描（CT）及动脉门静脉造影CT（CTAP）表现。对2个手术切除标本进行了组织学检查。
在13个病变中的10个（77%），CTAP显示肿瘤周边门静脉相关强化降低，提示门静脉血流减少。分别有40%、17%和3%的病例出现轻度萎缩（肝表面凹陷）、节段性萎缩和叶萎缩。切除标本的组织学检查显示，周围肝组织的外周门静脉内有组织化血栓形成。
PEI可能导致所治疗肿瘤周围的非癌性肝实质门静脉血流减少和萎缩。
