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Characterization of a reovirus isolate from a rattle snake, Crotalus viridis, with neurological dysfunction.

作者信息

Vieler E, Baumgärtner W, Herbst W, Köhler G

机构信息

Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, Federal Republic of Germany.

出版信息

Arch Virol. 1994;138(3-4):341-4. doi: 10.1007/BF01379136.

DOI:10.1007/BF01379136
PMID:7998838
Abstract

A virus isolate from the brain of a rattle snake with central nervous system (CNS) symptoms was identified as a reovirus. The isolate did not agglutinate pig erythrocytes and was not neutralized by antisera against avian reovirus S1133 and mammalian reovirus type 3. The cytopathic effect in Vero cells was characterized by formation of syncytial giant cells. Electrophoretic analysis of the genome revealed 10 segments of dsRNA. The isolate displayed characteristics distinct from avian and mammalian reoviruses.

摘要

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Extensive syncytium formation mediated by the reovirus FAST proteins triggers apoptosis-induced membrane instability.呼肠孤病毒FAST蛋白介导的广泛合胞体形成引发凋亡诱导的膜不稳定。
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Arch Virol. 1987;94(1-2):135-9. doi: 10.1007/BF01313731.
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