氯丁二烯的毒理学方面：即时和长期影响。
Aspects of the toxicology of chloroprene: immediate and long-term effects.
作者信息
Sanotskii I V
出版信息
Environ Health Perspect. 1976 Oct;17:85-93. doi: 10.1289/ehp.761785.
Abstract
The maximum permissible concentration (MPC) of chloroprene was set at 2 mg/m3 in the USSR in the 1940's. The existing MPC is 4 mg/m3. The threshold of systemic effects as a result of chronic chloroprene exposure is l.69 mg/m3. However, the threshold for embryotoxic and mutagenic effects is 0.15 mg/m3. In consideration of this information, setting a new MPC for chloroprene at 0.05 mg/m3 is recommended.
摘要
20世纪40年代，苏联将氯丁二烯的最大允许浓度（MPC）设定为2毫克/立方米。现行的MPC为4毫克/立方米。长期接触氯丁二烯产生全身影响的阈值为1.69毫克/立方米。然而，胚胎毒性和致突变作用的阈值为0.15毫克/立方米。考虑到这些信息，建议将氯丁二烯的新MPC设定为0.05毫克/立方米。
相似文献
1
Aspects of the toxicology of chloroprene: immediate and long-term effects.氯丁二烯的毒理学方面：即时和长期影响。
Environ Health Perspect. 1976 Oct;17:85-93. doi: 10.1289/ehp.761785.
2
Background information on chloroprene.氯丁二烯的背景信息。
J Occup Med. 1975 Apr;17(4):263-5.
3
[Establishing the value of the MPEL of chloroprene in the air of a work area].
Gig Tr Prof Zabol. 1976 Mar(3):31-6.
4
5
6
Chloroprene and polychloroprene.
IARC Monogr Eval Carcinog Risk Chem Hum. 1979 Feb;19:131-56.
7
Inhalation studies to evaluate the teratogenic and embryotoxic potential of beta-chloroprene (2-chlorobutadiene-1,3).
Toxicol Appl Pharmacol. 1978 Apr;44(1):81-8. doi: 10.1016/0041-008x(78)90286-7.
8
[Gonadotoxic and embryotoxic action of fluothane].
Gig Sanit. 1981 Apr(4):21-4.
9
[Results of a study of the mutagenic activity of chloroprene on microorganisms].
Zh Eksp Klin Med. 1976;16(5):39-41.
10
Short-term test for the induction of lung tumor in mouse by chloroprene.
Biomed Environ Sci. 1989 Jun;2(2):150-3.
引用本文的文献
1
Extended Analysis and Evidence Integration of Chloroprene as a Human Carcinogen.氯丁二烯作为人类致癌物的扩展分析和证据综合。
Risk Anal. 2020 Feb;40(2):294-318. doi: 10.1111/risa.13397. Epub 2019 Sep 16.
2
Spontaneous abortions among women employed in the metal industry in Finland.芬兰金属行业从业女性的自然流产情况。
Int Arch Occup Environ Health. 1980;47(1):53-60. doi: 10.1007/BF00378328.
3
Spontaneous abortions among female chemical workers in Finland.芬兰女性化学工人中的自然流产情况。
Int Arch Occup Environ Health. 1980 Feb;45(2):123-6. doi: 10.1007/BF01274131.
4
Community study of spontaneous abortions: relation to occupation and air pollution by sulfur dioxide, hydrogen sulfide, and carbon disulfide.自然流产的社区研究：与职业以及二氧化硫、硫化氢和二硫化碳造成的空气污染的关系。
Int Arch Occup Environ Health. 1982;51(1):55-63. doi: 10.1007/BF00378410.
5
Spontaneous abortions in an industrialized community in Finland.芬兰一个工业化社区中的自然流产情况。
Am J Public Health. 1983 Jan;73(1):32-7. doi: 10.2105/ajph.73.1.32.
6
Possibilities of detecting health effects by studies of populations exposed to chemicals from waste disposal sites.通过对接触来自废物处理场所化学物质的人群进行研究来检测健康影响的可能性。
Environ Health Perspect. 1985 Oct;62:423-56. doi: 10.1289/ehp.8562423.
7
Effects of paternal occupational exposure on spontaneous abortions.父亲职业暴露对自然流产的影响。
Am J Public Health. 1991 Aug;81(8):1029-33. doi: 10.2105/ajph.81.8.1029.
8
Mutagenic and carcinogenic risks associated with halogenated olefins.与卤代烯烃相关的致突变和致癌风险。
Environ Health Perspect. 1977 Dec;21:251-4. doi: 10.1289/ehp.7721251.
Zotero 插件