Bunetel L, Segui A, Langlais F, Cormier M
Laboratoire de Bactériologie, Faculté de Pharmacie, Hôpital Sud Rennes, France.
Eur J Drug Metab Pharmacokinet. 1994 Apr-Jun;19(2):99-105. doi: 10.1007/BF03188830.
17 sheep received femoral implantation of 'Cérafix Genta', containing gentamicin 0.6 or 1.2 g per dose either unilaterally (first 3 sheep) or bilaterally (remaining 14 sheep). Highest concentrations in bone were measured after 24 and 48 post-operative hours (respectively 36 and 72 mg/kg for Cérafix 0.6 g and 1.2 g). Gentamicin concentrations in bone marrow and femoral heads were in the same range. Blood and urine concentrations of gentamicin measured in sheep were comparable to those obtained in man. An extrapolation of the gentamicin behaviour from sheep to humans, might be possible: the sheep weight and femoral dimensions were comparable to those of humans and the method of implantation was similar in man and animal. For up to 18 months after operation, gentamicin levels in bone were always higher than critical concentration (4 mg/kg). For the early post-operative period, blood and urine levels always remained below gentamicin toxic concentrations.
17只绵羊接受了“Cérafix Genta”的股骨植入，每剂含庆大霉素0.6克或1.2克，其中3只绵羊为单侧植入，其余14只为双侧植入。术后24小时和48小时测量到骨内最高浓度（Cérafix 0.6克和1.2克分别为36毫克/千克和72毫克/千克）。骨髓和股骨头中的庆大霉素浓度处于相同范围。绵羊体内测得的庆大霉素血液和尿液浓度与人的相当。从绵羊到人类推断庆大霉素的行为可能是可行的：绵羊的体重和股骨尺寸与人的相当，并且植入方法在人和动物中相似。术后长达18个月，骨内庆大霉素水平始终高于临界浓度（4毫克/千克）。在术后早期，血液和尿液水平始终低于庆大霉素的毒性浓度。
