Elson R A, Jephcott A E, McGechie D B, Verettas D
J Bone Joint Surg Br. 1977 Nov;59-B(4):452-7. doi: 10.1302/0301-620X.59B4.925056.
In thirty-one rat tibiae, plugs of plain acrylic cement were inoculated with Staphylococcus aureus; these all remained contaminated at the end of two weeks when the animals were killed. Inoculation with known strains of Pseudomonas, Proteus and Gp. G Streptococcus resulted in 70 to 93 per cent persisting contamination. Gentamicin, to which the organisms were fully sensitive, was efficacious in controlling the infection (90 per cent plugs proving sterile after two weeks). Fucidin was less successful against Staphylococcus aureus although effective in vitro. Intravenous inoculation with a suspension of Staphylococcus aureus succeeded in contaminanting 70 per cent of sixty plain cement plugs when injected into the tail vein half an hour after closure of the leg wounds. Only 11 per cent of sixty-four plugs were so contaminanted when the injection was delayed for two weeks. This animal model is submitted as a possible future means of testing different antibiotic-cement combinations against infection.
在31只大鼠的胫骨中，将普通丙烯酸骨水泥塞接种金黄色葡萄球菌；当在两周结束时处死动物时，所有这些骨水泥塞仍被污染。接种已知的铜绿假单胞菌、变形杆菌和G群链球菌菌株导致70%至93%的骨水泥塞持续污染。庆大霉素对这些微生物完全敏感，能有效控制感染（90%的骨水泥塞在两周后无菌）。夫西地酸对金黄色葡萄球菌的效果较差，尽管在体外有效。当腿部伤口闭合半小时后经尾静脉注射金黄色葡萄球菌悬液时，静脉接种成功污染了60个普通骨水泥塞中的70%。当注射延迟两周时，64个骨水泥塞中只有11%被污染。这种动物模型被作为未来测试不同抗生素-骨水泥组合抗感染能力的一种可能方法提出。
