Sata M, Fukuizumi K, Uchimura Y, Nakano H, Ishii K, Kumashiro R, Mizokami M, Lau J Y, Tanikawa K
Second Department of Medicine, Nagoya City University Medical School, Japan.
J Viral Hepat. 1996 May;3(3):143-8. doi: 10.1111/j.1365-2893.1996.tb00005.x.
To determine the incidence of hepatitis C virus (HCV) infection in patients with alcoholic liver disease (ALD), serum samples from 252 patients with ALD were tested for anti-HCV and HCV RNA. Serial sera of these patients were collected and stored under optimal conditions to allow exact quantification of HCV RNA. Fifteen patients who visited our hospital during the same period of time with chronic HCV infections served as controls. In those with ALD, anti-HCV and HCV RNA were positive in 55.5% and 41.2%, respectively. Patients with histologically diagnosed chronic hepatitis and hepatocellular carcinoma had much higher prevalence rates of HCV RNA (84% and 100%, respectively) compared to those with fatty liver (4.3%), hepatic fibrosis (10.1%) and alcoholic hepatitis (22.2%) (P < 0.01). Although no difference in serum HCV RNA levels was observed between the patients with both ALD and chronic HCV infection and those with chronic HCV infection alone, HCV RNA levels significantly (10-fold) dropped after abstinence in nearly half of the patients (P < 0.01). These data indicate that HCV infection in patients with ALD promotes progression of liver disease, and abstinence from alcohol is associated with a reduction in serum HCV RNA levels.
为确定酒精性肝病（ALD）患者丙型肝炎病毒（HCV）感染的发生率，对252例ALD患者的血清样本进行了抗-HCV和HCV RNA检测。收集这些患者的系列血清并在最佳条件下储存，以便对HCV RNA进行精确定量。同期就诊的15例慢性HCV感染患者作为对照。在ALD患者中，抗-HCV和HCV RNA阳性率分别为55.5%和41.2%。与脂肪肝（4.3%）、肝纤维化（10.1%）和酒精性肝炎（22.2%）患者相比，经组织学诊断为慢性肝炎和肝细胞癌的患者HCV RNA患病率更高（分别为84%和100%）（P<0.01）。虽然同时患有ALD和慢性HCV感染的患者与单纯慢性HCV感染患者的血清HCV RNA水平无差异，但近一半患者戒酒后HCV RNA水平显著下降（10倍）（P<0.01）。这些数据表明，ALD患者的HCV感染会促进肝病进展，戒酒与血清HCV RNA水平降低有关。
