Biological Sciences, University of Southampton, United Kingdom.
Biological Sciences, University of Southampton, United Kingdom.
Neuroscience. 2019 May 1;405:24-34. doi: 10.1016/j.neuroscience.2018.01.059. Epub 2018 Feb 8.
The understanding of the contribution of microglial cells to the onset and/or progression chronic neurodegenerative diseases is key to identify disease-modifying therapies, given the strong neuroimmune component of these disorders. In this review, we dissect the different pathways by which microglia can affect, directly or indirectly, neuronal function and dysfunction associated with diseases like Alzheimer's. We here present the rationale for proposing a model to explain the contribution of microglia to the pathophysiology of Alzheimer's disease, defining microglial cells as necessary transducers of pathology and ideal targets for intervention.
理解小胶质细胞对慢性神经退行性疾病的发病和/或进展的贡献对于确定疾病修饰疗法至关重要，因为这些疾病具有强烈的神经免疫成分。在这篇综述中，我们剖析了小胶质细胞可以直接或间接地影响与阿尔茨海默病等疾病相关的神经元功能障碍和功能障碍的不同途径。我们在这里提出了一个解释小胶质细胞对阿尔茨海默病病理生理学贡献的模型的基本原理，将小胶质细胞定义为病理的必要转导器和干预的理想靶点。
